MAPK
Millipore offers hundreds of premium quality antibodies, enzymes, siRNA and kits for MAPK signaling research. MAPK/Erks present great potential as targets for anticancer agents due to their role in cell division, migration and survival. One of their most important functions, however, may involve their role in neural function. Although neurons are terminally differentiated, many Erk targets typically thought to mediate the cell cycle are present in these cells. MAPK regulates the phosphorylation of tau and the processing of Ab, both of which are critical to Alzheimer’s Disease pathology. Erk activation is required, not only for certain forms of long-term potentiation (LTP), but also for the acquisition and retention of particular memories. The cellular processes underlying such functions also rely on Erk activation. For example, MEK inhibitors block increases in AMPA Receptor (AMPAR) number and activity, a change thought to underlie learning. Long known to be important for synaptic plasticity, CamKII-dependent insertion of AMPARs into synapses also requires Erk. MEK inhibitors inhibit both Erk activation and the formation of new spines. | Anti-Phospho-MAPK 1/2 (Erk 1/2) WB: Non-stimulated PC-12 (Lane 1) or NGF-stimulated PC-12 (Lane 2) cell lysates were probed with Ant-phospho-MAPK 1/2 (Erk 1/2) (2 µg/mL), Millipore cat. no. 05-481. |
References
- Ahn S, Wei H, Garrison TR, Lefkowitz RJ. Reciprocal regulation of angiotensin receptoractivated extracellular signal-regulated kinases by b-arrestins 1 and 2. JBC. Feb 2004; 279(9):7807–11.
- Toy-Miou-Leong M, Cortes CL, Beaudet A, Rostene W, Forgez P. Receptor trafficking via the perinuclear recycling compartment accompanied by cell division is necessary for permanent neurotensin cell sensitization and leads to chronic mitogen-activated protein kinase activation. JBC. Mar 2004; 79(13): 12636–46.
- He HJ, Kole S, Kwon YK, Crow MT, Bernier M. Interaction of filamin A with the insulin receptor alters insulin-dependent activation of the mitogenactivated protein kinase pathway. JBC. Jul 2004; 278(29): 27096–104.
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