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Multipotent Stem Cell Research

In addition to pluripotent stem cells derived from fetal tissues, stem cells have been identified in a diverse range of adult tissues and organs, including neural stem cells in the brain and hematopoietic stem cells in bone marrow. In contrast to early notions that adult stem cells are committed to differentiate exclusively into the tissues of the same histogenetic origin, recent evidence suggests that adult stem cells may have the potential to differentiate into tissues outside of their original lineage (Jackson et al., 1999, PNAS; Petersen et al., 1999, Science; Krause et al., 2001, Cell). This phenomenon, termed plasticity, includes differentiation into cells of the same primary germ layer or an alternate germ layer.

Examples of adult stem cell plasticity include the differentiation of neural stem cells into blood cells (Bjornson et al., 1999, Science) muscle cells (Galli et al., 2000, Neuroscience) and a variety of cells representing all three-germ layers (Clarke, 2000, Science). The advancement of adult stem cell biology requires specific research tools that allow the isolation, expansion and characterization of stem cells. Additionally, the characterization of progenitor cells following stem cell differentiation is critical for the analysis of their therapeutic potential. Millipore has an extensive range of products for the purification, expansion and analysis of neural, hematopoietic and endothelial stem cells.

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Product News & Releases

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Featured Products

• ENStem-A Human Neural Progenitors
• ReNcell Human Neural Progenitors
• HEScGRO Human Embryonic Stem Cell Medium
• Cardiac Stem Cell Isolation Kit
• Mouse Embryonic Stem Cell Neurogenesis Assay
• Cellntec Products for Bladder Research
• Steriflip Filter Units
• Stem Cell Tested Filter Units
• Epidermal Growth Factors

Pathways