• Login
|
• Register
|
• My Account
|
• Shopping Cart
|
• Help

Phospholipases and PI 3-Kinase Activity

Phosphoglycerides are the starting point for the generation of several critical signaling second messengers produced by PI 3-Kinase and Phospholipase A, C or D (PLA, PLC or PLD). There are many phosphoglycerides, only PIP₂ (phosphatidylinositol 4,5-bisphosphate) is shown, and a few others are described here (see table). PIP₂ is the substrate for PI 3-Kinase and PLC. PI 3-Kinase phosphorylates PIP₂ to produce PIP₃, which is in turn the substrate for the lipid phosphatase PTEN. PLC hydrolyzes PIP₂ to produce DAG (diacylglycerol) and IP3 (inositol 1,4,5-trisphosphate). PC is the substrate for the PLAs and for PLD, which produce lyso-PC and arachidonic acid, or PA and choline, respectively. PLA isoforms recognize different sites on PC; PLA₁ removes the external fatty acid, while PLA₂ cleaves off the internal. All of the end products of PI 3-Kinase and the phospholipases are critical second messengers which stimulate downstream signal transduction pathways, or are key building blocks for other important biological processes.

 

Phosphogyceride	Abbreviation	Headgroup
Pl 4,5-biphosphate	PIP2	Inositol 4.5-bisphosphate
Pl 3,4,5-triphosphate	PIP3	Inositol 4.5-trisphosphate
Phosphatidylcholine	PC	choline
Phosphatidic acid	PA	OH

back to top

// this function fires when the user has clicked on a tab var onTabClicked = function(tabIndex, obj) { window.location.href = getBaseURL() + "#" + tabIndex; AntibodiesNavigatorPanels.setSelectedIndex(tabIndex); } mainSimpleTabs=new SimpleTabs("find_antibodies", 0, onTabClicked); AntibodiesNavigatorPanels.addNavigatorPanel(new NavigatorPanel("primary_antibodies_form", "primary_antibodies_filter", "/pages/microsites/antibodies/primary_antibodies_filter.jsp?navigatorPanelSet=AntibodiesNavigatorPanels", true)); AntibodiesNavigatorPanels.addNavigatorPanel(new NavigatorPanel("secondary_antibodies_form", "secondary_antibodies_filter", "/pages/microsites/antibodies/secondary_antibodies_filter.jsp?navigatorPanelSet=AntibodiesNavigatorPanels")); AntibodiesNavigatorPanels.setSelectedIndex(getTabIndex()); AntibodiesNavigatorPanels.populateFilters(); mainSimpleTabs.setTab(getTabIndex()); if (disableToggle) { $("toggleAdv").style.display = "none"; } AntibodiesNavigatorPanels.getNavigatorPanel(0).setToggleImageId("toggleAdv"); AntibodiesNavigatorPanels.setShowAll(true);

• Primary
• Secondary

Find Primary Antibodies

Enter a keyword and/or search criteria below. Or you may also use selections below to browse specific antibodies for your needs.

Keyword Gene Symbol UniProt Number Entrez Gene Number

Advanced Options

---

Find Secondary Antibodies

Select the host, conjugate, and species, and then press Search to find the secondary antibodies for your research needs.

Product News & Releases

• Faster Flow Rates for Sterile Filtration - New Millex® syringe filters with Millipore Express PLUS (PES) membrane
• ReNcell® VM Neural Stem Cell Line Models Parkinson’s Disease - New human disease model shows function of PINK1 gene in neural degeneration
• Millipore Issues New Laboratory Filtration Product Guide
• Millipore Launches Progenitor Cell-Enriched Primary Human Epithelial Cell Cultures

Featured Products

• Fast-Trap Lentivirus Purification and Concentration Kit
• Fast-Trap Adenovirus Purification and Concentration Kit
• EasyCyte Plus Flow Cytometry System
• ECM Cell Culture Optimization Arrays
• ESGRO Complete
• GCTM-5 Antibody, clone GCTM-5
• Guava Viacount Assay
• MilliTrace Constitutive GFP Reporter
• MultiScreen_HTS + and MultiScreen Vacuum Manifolds
• ENStem-A hES-derived Human Neural Progenitors

Pathways