UCOE™ Expression Technology
UCOE™ (Ubiquitous Chromatin Opening Element) expression vector technology gives major improvements in gene expression in stably-transfected mammalian cells through effects on the structure of chromatin. UCOE expression technology prevents transgene silencing and gives consistent, stable and high-level gene expression irrespective of the chromosomal integration site. UCOE expression elements are small DNA elements (isolated from the area around house-keeping genes, which need to be active most of the time) that create a transcriptionally active, open chromatin environment around an integrated transgene, maximizing its potential to be transcribed into protein, irrespective of the position of the transgene in the chromosome. For more information, click here.If you are interested in obtaining a license for the UCOE™ expression vector technology, please contact Trish Benton at trish.benton@merckgroup.com (North America) or John Wynne at john.wynne@merckgroup.com for further information.
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