> Last Item Added:
0 Items

Understanding the Options

Large Volume Parenterals (LVP)



Prefiltration
Essential Process Requirements
  • Remove colloidal and particulate contaminants
  • Preserve product purity
  • Operate consistently at high differential pressures and flow rates
  • Prevent plugging and extend the life of downstream filters
  • Able to withstand demanding sanitization cycles
  • Run efficiently to ensure process economics
  • Solute concentration impacts filter selection
Recommended FilterFilter Characteristics

Double-layer Milligard Filters
(Grade SS, 0.5 µm + 0.2 µm, or Grade SC, 1.2 µm + 0.5 µm)

Cartridge Filters

Opticap Capsule Filters

Optiscale Capsule Filters
  • Double-layer pleated configuration of mixed esters of cellulose membranes remove particles and colloids
  • High porosity membranes operate at high flow rates and low pressure drops
  • Better suited for low-solute concentrations
  • Non-fiber releasing structure preserves product purity
  • 100% integrity tested to ensure quality
  • Robust construction validated to withstand multiple SIP or hot water sanitization cycles
  • Available in a variety of pore sizes to accommodate the needs of each user. Grade SS is commonly used to protect downstream 0.22 µm sterilizing-grade filters. Grade SC is better suited to protect 0.45 µm membrane filters. Choice should be made based on small-scale testing.

Double-layer Polysep II Filters
(Grade W6, 1 µm + 0.5 µm, or Grade W3, 1 µm + 0.2 µm)

Cartridge Filters

Opticap Capsules

Optiscale Capsules
  • Borosilicate glass top layer enhances particle and loading capacity in high solute applications
  • Mixed esters of cellulose membrane bottom layer ensures high retention and filtrate quality
  • Ideal for high solute concentration such as 5% Dextrose
  • Robust construction validated to withstand multiple SIP or hot water sanitization cycles
  • Non-fiber releasing structure preserves product purity
  • 100% integrity tested to ensure quality
  • Available in a variety of pore sizes to accommodate the needs of each user. Grade W3 is commonly used to protect downstream 0.22 µm membrane filters. Grade W6 is better suited to protect 0.45 µm membrane filters. Choice should be made based on small-scale testing.

Bioburden Reduction
Essential Process Requirements
  • Reduce bioburden prior to terminal sterilization
  • Preserve product purity
  • Operate consistently at high flow rates
  • Able to withstand demanding sanitization requirements
Recommended FilterFilter Characteristics

Double-layer Durapore 0.45 µm Filters
(with 0.5 µm prefilter layer)

Cartridge Filter

Optiseal Cartridge Filters

Opticap Capsule Filter
  • Low protein-binding PVDF membrane with prefilter
  • Retentive membrane reduces bioburden
  • Low extractables and non-fiber releasing PVDF chemistry preserve product purity and yield
  • High flow rate at low pressure drop for reliable economic processing100% integrity tested to ensure quality
  • validated for multiple SIP and hot water sanitization cycles


Durapore CBR 0.2 µm Filters
  • Low protein-binding 0.2 µm PVDF membrane
  • Bacterial retentive membrane reduces bioburden
  • Low extractables and non-fiber releasing PVDF chemistry preserve product purity and yield
  • High flow rate at low pressure drop for reliable economic processing
  • 100% integrity tested to ensure quality
  • Validated for multiple SIP and hot water sanitization cycles
Final Sterile Filtration
Essential Process Requirements
  • Sterile filtration prior to terminal sterilization
  • Operate consistently at high differential pressures and flow rates
  • Able to withstand rigorous sanitization and process requirements
  • Ensure product safety
Recommended FilterFilter Characteristics

Double-layer Durapore 0.45 µm Filters
(with 0.5 µm prefilter layer)

Cartridge Filter

Optiseal Cartridge Filters

Opticap Capsule Filter
  • Low protein-binding PVDF membrane with prefilter
  • Retentive membrane reduces bioburden
  • Low extractables and non-fiber releasing PVDF chemistry preserve product purity and yield
  • High flow rate at low pressure drop for reliable economic processing
  • 100% integrity tested to ensure quality
  • Validated for multiple SIP and hot water sanitization cycles

ALTERNATIVE: If a PES membrane is required, Millipore suggests including Millipore’s Express SHF Filters in your screening trials.