Influenza Viruses
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Millipore offers a wide variety of antibodies for the detection of respiratory viruses, including influenza A and B viruses. These are large enveloped viruses, about 110 nm in diameter, with hemaglutinin (HA) and neuraminidase (NA) projections protruding through the glycoprotein membrane, and contain a segmented, single-stranded RNA genome. Both viruses have a high frequency of periodic antigenic shifts and cause periodic epidemics of influenza worldwide. These pandemics are particularly severe when mutations have resulted in dramatic changes in the HA or NA structure such that the virus strains are not recognized by circulating antibodies in a community of people. Millipore offers a wide selection of monoclonal and polyclonal antibodies for various strains of Influenza A and B. The following tables show the specificity of the monoclonal and polyclonal antibodies for Influenza A and B that are currently available from Millipore.

Many of these antibodies may be further modified to meet your application requirements including conjugation and purification. To learn more about our products and services or to discuss your specific assay needs:

Millipore Infuenza A Monoclonal Antibodies
Product Catalogue # Description Reactivity Format
MAB8256-K Anti-Influenza A,
H1N1		 Reacts strongly with all H1N1 strains tested including Beijing, A/ Texas /36/91, A/Berkeley/1/98, A/HongKong/503/97, A/Nanchang /16A/98,A/PR/8/34, New Caledonia strain, and the 2009 A/Swine/H1N1 Ascites mouse
MAB8261-K Anti-Influenza A,
H1N1		 Reacts strongly with all H1N1 strains tested including Beijing, A/ Texas /36/91, A/Berkeley/1/98, A/HongKong/503/97, A/Nanchang /16A/98,A/PR/8/34, New Caledonia strain, and the 2009 A/Swine/H1N1 Purified mouse ascites
MAB8252-K Anti-Influenza A,
H-1 Antigen		 MAB8252 reacts with all strains of H1N1 up to 1997-98 except A/Texas/136/91 and most since then (also A/Taiwan/1/86). Reacts strongly with the following H1N1 strains: A/Taiwan/1/86, A/USSR/90/77, and all CA strains 1986 to present. • Does not react well with A/Texas/36/91; or the New Caledonia strain (after 1998) or the 2009 A/Swine/H1N1 A/Swine/H1N1 Purified mouse ascites
MAB8253-K Anti-Influenza A,
H-1 Antigen		 MAB8253 is known to react with A/Taiwan/1/86 and A/Texas/136/91 These antibodies are essentially the same but bind to different epitopes. Both of these antibodies do not bind the Swine Flu A H1N1 2009 as well as MAB8256 which reacts strongly. Reacts strongly with the following H1N1 strain. • Does not react well with 2009 A/Swine/H1N1 Purified mouse ascites
MAB8254-K Influenza A,
H-3 Antigen		 MAB8254 reacts with the H3 of most H3N2 including Wuhan/396/95 and Shanghai/16/84 etc. Reacts strongly with the following H3N2 strains: A/Wuhan/396/95; A/Johannesburg/33/94; A/Shandung/93; A/Shanghai/16/89; All CA Strains 1986 to Present. Purified mouse ascites
MAB8255-K Influenza A,
H-3 Antigen		 MAB8255 does not react with Wuhan/359/95 but does react with Shanghai/11/87 etc. These antibodies are similar but bind a different epitope. Reacts strongly with the following H3N2 strain: A/Shanghai/11/87. No reactivity shown with the following H3N2 strain: A/Wuhan/359/95\ Purified mouse ascites
Millipore Infuenza B Monoclonal Antibodies
Product Catalogue # Description Reactivity Format
MAB8257-K Anti-Influenza A,
N1 Nucleoprotein		 Specific for the Influenza A nucleoprotein. Has stronger binding with N1-type Flu A. No cross reactivity seen to influenza B or other respiratory viruses. Shown to react with Avian H5N1 strain and 2009 A/Swine/H1N1. Purified
MAB8671-K Anti-Influenza B
Core protein		 Recognizes Influenza B, anti-core specific; reacts with all strains of Influenza B tested. No reactivity with Flu A or other respiratory viruses. Purified mouse ascites
MAB8258-K Anti-Influenza A,
N2/N3 Nucleoprotein		 MAB8259 recognizes Influenza B nucleoprotein (on all strains tested). Specific for the influenza A nucleoprotein. Stronger reactivity is observed with N2/N3-type Flu A strains. No cross reactivity seen to Influenza B or other respiratory viruses. Purified mouse ascites
MAB8251-K Anti-Influenza A
Blend		 A blend of MAB8257 and MAB8258 Ascites, mouse
MAB8259-K Anti-Influenza B
Nucleoprotein		 Specific for the nucleoprotein antigen of Influenza B. No cross-reactivity to influenza A, parainfluenza 1, 2 or 3, Adenovirus or RSV. Purified mouse ascites
MAB8260-K Anti-Influenza B
Nucleoprotein		 MAB8260 recognizes Influenza B haemagglutinin (on all strains tested). Specific for the nucleoprotein antigen of Influenza B. No cross-reactivity to influenza A, parainfluenza 1, 2 or 3, adenovirus or RSV. Purified mouse ascites
MAB8661-K Anti-Influenza B
Blend		 A blend of MAB8259 and MAB8260 Ascites, mouse

Many of these antibodies may be further modified to meet your application requirements including conjugation and purification.
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