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Filtration Products


» Sterilizing-grade Membranes
» Clarification Media
» Filter Types

Millipore offers disposable filters for all the stages in your process. From upstream prefiltration and clarification to downstream separation and sterile filtration, Millipore has filters and media types that meet your needs. Our scalable solutions support small-scale process development through pilot production with devices like Millipak filters. For larger-scale production applications, Millipore’s Opticap XL and XLT disposable capsules are available in a wide range of sizes, fittings and filter media.


Sterilizing-grade Membranes
Durapore Membrane Filters - PVDF (Polyvinylidene fluoride)

The Durapore membrane provides high flow rates and throughput, low extractables and broad chemical compatibility. Hydrophilic Durapore membranes bind far less protein than nylon, nitrocellulose or PTFE membranes.

Pore sizes: 0.1, 0.22, 0.45, 0.65, 5 µm
Wettability: Hydrophilic, hydrophobic
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Express Membrane Filters- PES (Polyethersulfone)
Millipore’s Express PES (Polyethersulfone) membrane is a caustic-compatible, high-throughput, low-protein binding membrane that provides ultrafast filtration of tissue culture media, additives, buffers and other aqueous solutions.

Pore sizes: 0.1, 0.2 µm, and multi-layer
Wettability: Hydrophilic
pH Compatibility: 1-14

Choose from a variety of Express Membrane sterilizing-grade PES filters, including:
  • SHR (Sterile, High Retention) Filters: recommended for the removal of mycoplasma and other small microorganisms that can pass through a 0.2 μm rated sterilizing grade filter.
  • SHC (Sterile, High Capacity) Filters: designed for use across a range of low to high-fouling process solutions including cell culture media and media additives.  
  • SHF (Sterile, High-Flux) Filters: designed with a broad chemical compatibility, exceptionally high flow rates for buffers, low extractables and high-flux performance with a full range of buffer chemistries.
Clarification & Prefiltration Media
Millistak+ HC Filters dual-action media improves prefiltration and compresses clarification. Millistak + HC filters are stacked depth filters specifically designed for mammalian cell fermentation processes. A unique combination of charged media and cellulosic membrane compress multiple steps into one high-performance solution that saves time and resources.

Milligard pleated cellulosic multimedia filters offer the finest prefiltration levels available, providing unsurpassed protection of the final sterilizing filter from premature plugging. Ideal for cell culture media, mammalian cell culture, buffer preparation, serum, SVP, LVP and plasma protein applications.

Polysep II pleated multimedia filters combine borosilicate glass fiber with mixed esters of cellulose providing much higher retention efficiency for more critical degrees of prefiltration. Ideal for cell culture media, serum, buffer preparation, LVP and ophthalmic applications.

Lifegard pleated prefilters offer increased adsorptive capacities with borosilicate glass microfiber media, an excellent solution for deformable particle retention. Ideal for plasma protein, serum and vaccine production.

Clarigard high performance polypropylene depth filters are comprised of fine diameter polypropylene fibers within an optimized graded density structure. The resulting cartridge filter provides superior retention of particulate and bioburden as well as enhanced throughput capacity. Ideal for facilities, beverage, media, and bulk chemical filtration applications.

Polygard-CN polypropylene filters provide high retention efficiency, high flow rates, and high dirt-holding capacity with a melt-blown medium fabricated in a pleated format. Best suited for fine clarification applications such as; facilities, beverage, and bulk chemical filtration that require broad chemical compatibility.

Polygard-CR polypropylene depth filters offer moderately high retention efficiency, high flow rates, and high dirt-holding capacity by virtue of a graded density of concentrically wrapped media. Best suited for course clarification applications such as; facilities, beverage, and bulk chemical filtration that require broad chemical compatibility.

Learn more about our clarification and prefiltration products.

Filter Types
Process Scale Capsule Filters
Millipore offers two sterile capsule options, Opticap XL and XLT. Sterile capsules are gamma irradiated, and available in a wide range of sizes for easy scale-up. Capsule filters are available with a variety of media including Durapore, Express SHC, SHF and SHR membranes.
Opticap XL disposable capsule filters are designed to minimize hold-up volume and reduce production losses. Opticap XL capsules are available in 2, 4, 5 and 10-inch lengths.

Opticap XLT disposable T-line capsule filters can accommodate series or parallel filtration, and can be fitted with a pressure gauge port to make monitoring easy. The Opticap XLT capsules are available in 10, 20 and 30-inch lengths.

Scalable and Small Scale Capsule Filters
Millipak Disposable Filter Units are stacked disc filters designed for the removal of particles and microorganisms from liquids and gases. The stacked disc design allows minimal hold-up volume and particle shedding. Millipak units are made with Durapore PVDF membranes and available in 0.1 µm, 0.22 µm and 0.45 µm pore sizes with a variety of inlet and outlet connections.

Opticap XL 150, 300, 600 capsules are ideal for small-volume sterile filling applications and process development. They are recommended for processing starting at 20L, and include a choice of Express SHR or SHC membranes.
Pod Filters
The innovative Pod filter system is a modular, disposable NFF filter format that delivers unprecedented flexibility for clarification and prefiltration applications. Available with Millistak+ HC , the self-contained, disposable design of the Pod platform gives you the ability to improve process speed, safety and economics in your clarification step.


Need help selecting the best filter for your needs?

»»Learn more...
Filtration Selection Guide:
Chose the Right Filter for Your Application

Disposable Assemblies
Millipore provides complete liquid management systems in custom and standard configurations, including systems designed for specific applications. Learn more about Millipore’s disposable assemblies.


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