Millipore Tyrosine Kinases with BioForm Technology

Enhance phosphorylation with BioForm-enabled assembly

MILLIPORE TYROSINE KINASES COUPLED WITH INNOVATIVE BIOFORM TECHNOLOGY PROVIDE A BETTER, MORE BIOLOGICALLY RELEVANT ENVIRONMENT FOR YOUR RESEARCH AND DISCOVERY EFFORTS

Tyrosine phosphorylation of and by transmembrane proteins is one of the key steps in so much of today’s research, from early stage drug screening to signal transduction and regulation of enzymatic activity. Yet studying this step can be challenging. For years, the solution has been to settle on receptor fragments commercialized for pair-wise interactions. However, much information is lost in these experiments since signaling proteins need other ‘team members’ to become fully functional. This activity typically arises from the assembly of a complex signaling team formed near the membrane surface. Analysis of a single protein interacting with a single partner loses the rich, two-dimensional information afforded by the membrane surface.

A BETTER WAY TO STUDY TRANSMEMBRANE RECEPTORS

At Millipore, we’re committed to providing you with the best tools so you can focus on what matters most: advancing your research forward. That’s why we’re proud to offer BioForm technology that enables you to assemble histidine-tagged proteins in a way that mimics the environment created by the cell membrane. This synthetic template, now bundled with select tyrosine kinases, restores the organizing features of the membrane without the difficulties of membrane preparation and reconstitution procedures.

ASSEMBLE COMPLEX PATHWAYS IN VITRO

BioForm technology’s unique protein-assembly capability leads to biologically relevant function and the flexibility to assemble complex pathways easily and effectively in vitro. With BioForm technology, you receive an enhanced, more biologically relevant environment for your research. And as life scientists ourselves, we know that when you have the tools you need to work more efficiently, the results can be life-altering.

BioForm Technology Highlights:

Facilitates the assembly of active signaling complexes
Adaptable to high throughput assay format
Creates biologically relevant assay condition
Applicable to many signaling systems

Use BioForm Technology for:

Early stage drug screening
Lead identification
A new avenue for target identification
Testing biological effects downstream of your target
Signal transduction research
Functional, in vitro assembly of multiple protein targets.

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Millipore’s Upstate Kinases with BioForm Technology

Ordering Information
Description	Catalog Number	Pack Size Description
BTK and BioForm	30-118	14-552 (10 ug) and 12-711 (100 assays)
EphB2 and BioForm	30-119	14-553 (10 ug) and 12-711 (100 assays)
IGF-1R and BioForm	30-120	14-465 (10 ug) and 12-711 (100 assays)
IR and BioForm	30-121	14-466 (10 ug) and 12-711 (100 assays)
Met and BioForm	30-122	14-526 (10 ug) and 12-711 (100 assays)
Tie2 and BioForm	30-123	14-540 (10 ug) and 12-711 (100 assays)
Lck and BioForm	30-124	14-442 (10 ug) and 12-711 (100 assays)
Fak and BioForm	30-125	14-720 (10 ug) and 12-711 (100 assays)
ErbB4 and BioForm	30-126	14-569 (10 ug) and 12-711 (100 assays)
PKCg and BioForm	30-127	14-483 (10 ug) and 12-711 (100 assays)
Axl and BioForm	30-128	14-512 (10 ug) and 12-711 (100 assays)
TrkB and BioForm	30-129	14-507 (10 ug) and 12-711 (100 assays)
TrkA and BioForm	30-130	14-571 (10 ug) and 12-711 (100 assays)
Flt1 and BioForm	30-131	14-562 (10 ug) and 12-711 (100 assays)

BioForm Reagent

Ordering Information
Description	Catalog Number
BioForm, 100 assays	12-711
BioForm, 250 assays	12-712
BioForm, 500 assays	12-713