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Drug Discovery Safety & Liability Screening Panel

In the high-stakes business of drug development, early safety assessment across a range of targets is critical. When you know everything you can about your drug candidates—including potentially devastating off-target liabilities—you’re able to avoid costly errors and quicken the pace toward developing compounds that offer the greatest promise of success.

Know More About Your Drug Candidates

The new Millipore Drug Discovery Safety & Liability Screening Panel addresses this critical need by providing industry-leading, functional profiling against 125 GPCR, kinase, ion channel and phosphatase targets. These targets were specifically chosen for their relevance to critical diseases and processes, including neurotoxicity, cardiac function, immunoprotection, diabetes, inflammation and gastrointestinal liability.

Millipore’s Drug Discovery Safety & Liability Screening Panel offers:

• 125 critical safety targets across four target classes
• Recognized quality and service from four of our premier functional profiling services—KinaseProfiler, PhosphataseProfiler, GPCRProfiler and CardiacProfiler—in one convenient service panel
• Single compound shipping point to your choice of the US or UK, reducing your shipping and administrative costs
• Convenient monthly schedule with three-week turnaround time from compound submission deadline
• Secure access to your constituent reports as soon as they are completed via the Millipore online Drug Discovery Portal
• Valuable insight into your compound’s potential off-target liabilities at an extraordinary value

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For more information, contact Millipore's Drug Discovery Services team at drugdiscovery@millipore.com.

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View Sample Data

• Millipore GPCR Safety Panel vs BIRB0796
• Millipore Kinase & Phosphatase Safety Panel vs. BIRB0796
• BIRB0796 Inhibition of Cardiac Ion Channels

Targets Available in the Drug Discovery Safety & Liabilty Screening Panel

Family Target Name Species Protein Kinase - radiometric enzyme assay AGC PKA human PKBβ human PKCm human PKCz human PKCα human PKCβI human PKCβII human PKCγ human PKCδ human PKCε human PKCη human PKCθ human PKCι human PKG1ß human PKG1α human ROCK-II human CAMK AMPK rat CaMKII β human CaMKII γ human CaMKII δ human LKB1 human CMGC CDK1/cyclinB human CDK2/cyclinA human CDK2/cyclinE human CDK3/cyclinE human CDK5/p25 human CDK5/p35 human CDK7/cyclinH/MAT1 human CDK9/cyclinT1 human GSK3b human MAPK1 human MAPK2 human p70 S6 Kinase human SAPK2a human Misc PhKγ2 human TK Abl human Flt3 human IR human Lyn human Protein Phosphatase - fluorescent enzyme assay Tyrosine phosphatase PTP1B human TCPTP human Ion Channel - cellular electrophysiology assay Voltage-gated sodium channel Nav1.5 human Inactivating potassium channel hKv4.3/hKChIP2 human Voltage-gated calcium channel L-type Calcium (Cav1.2) human Ultra-rapid potassium channel hKv1.5 human Slow potassium channel hKCNQ1/hminK human Rapid potassium channel hERG human Hyperpolarization gated channel hHCN4 hKir2.1 human human		Family Target Name Species GPCR - cellular calcium flux assay Acetylcholine (muscarinic) M1 human M2 human M3 human Adenosine A1 human A3 human Adrenergic alpha1A human alpha1D human alpha2A human beta 1 human beta 2 human Anaphylotoxin C5aR human Angiotensin AT1 human Bombesin BB2 human Bradykinin B2 human Calcitonin CGPR1 human Cannabinoid CB1 human CB2 human Chemokine CCR1 human CCR2B human CX3CR1 human CXCR1 human Cholecystokinin CCK2 human CRF Receptor CRF1 human Dopamine D1 human D2L human D5 human Endothelin ETA human ETB human Galanin GAL1 human Glycoprotein hormone TSH human GnRH GnRH / LHRH human Histamine H1 human H2 human H3 human Leukotriene BLT1 human CysLT1 human Lysophospholipid LPA1 human LPA3 human S1P3 human Melanocortin MC5 human Motilin Motilin receptor, MTLR human Neuromedin U NMU1 human Neuropeptide Y Y2 human Neurotensin NTR1 human N-formylpeptide FPR1 human Nicotinic Acid GPR109A human Opioid Delta human Kappa human Mu human Orexin OX1 human Oxytocin OT human P2Y / Purinergic (metabotropic) P2Y1 human Platelet Activating Factor PAF human Prokineticin PK1 human Prolactin-releasing peptide PRP human Prostanoid DP human EP2 human EP3 human FP human IP1 human TP human Protease-activated PAR4 human PTH receptor PTH1 human Serotonin 5-HT1A human 5-HT2A human 5-HT2B human 5-HT2C human Somatostatin SST4 human Tackykinin /neurokinin NK1 human NK3 human Urotensin II UT / GPR14 human Vasopressin V1A human V2 human VIP/PACAP PAC1 long isoform human VPAC1 human VPAC2 human

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