CardiacProfiler Service
The CardiacProfiler offers a fully validated panel of functional profiling assays specifically chosen to provide a more thorough assessment of the true cardiac liability of drug candidates. The service utilizes PrecisION ion channel cell lines which were carefully selected for their optimal performance on the IonWorks instrument platform thus ensuring a high level of assay accuracy and precision. PDF: CardiacProfiler
| Description | Catalogue Number |
| hERG CardiacProfiler Service: The hERG CardiacProfiler Service is a flexible contract service which allows for the evaluation of compounds using the IonWorks HT and a PrecisION CHO cell line (Cat. No. CYL3038) functionally expressing the hERG ion channel. The flexibility of the service allows for the submission of variable sample numbers depending on the requirements of the customer. | CYL6023 |
| hKCNQ1/hminK CardiacProfiler Service | CYL5007QU |
| hHCN4 CardiacProfiler Service | CYL5012HT |
| hKv4.3/hKChIP1 CardiacProfiler Service | CYL5027QU |
| hNav1.5 CardiacProfiler Service | CYL5004HT |
| hKv1.5 CardiacProfiler Service | CYL5018HT |
| hCav1.2 CardiacProfiler Service | CYL5051QU |
| Cardiac 7-Profiler Service: The Cardiac 7-Profiler Service is offered as a monthly profiling service that allows for the comprehensive functional assessment of drug candidates against hERG, hKCNQ1/hminK, hKv1.5, hNav1.5, hHCN4, hKv4.3/hKChIP1 and hCav1.2 ion channels. Collectively, these cardiac ion channels play a critical role in the normal functioning of the human heart and were chosen to provide a more thorough assessment of the true cardiac liability of drug candidates. The Cardiac 7-Profiler Service utilizes seven distinct PrecisION ion channel cell lines, each of which were genetically modified to functionally express a single type of cardiac ion channel. All of the cell lines were optimized for use on either the IonWorks HT or Quattro automated patch clamp instruments | CYL9000 |
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