MILLIPLEX MAP
& Cell Signaling Pathways

Cell signaling, often called signal transduction, is a complex system of communication that enables cells to perceive, communicate with and respond to their microenvironment. This communication may occur as a result of:

Direct cell-to-cell contact
Effects that are induced when a receptor that has been activated by a ligand interacts directly with other proteins inside the cell
Cellular changes resulting from complex signal transduction pathways involving kinase receptors that, when bound to a ligand, become phosphorylated

Phosphorylation can generate a binding site for a different secondary protein, inducing a protein-to-protein interaction that enables signal transduction. A terminal signaling event, such as a transcription factor, is phosphorylated, resulting in the activation that ultimately affects, for example, cell cycle progression. These multi-component cell signaling pathways are so complex that often there is feedback, signal amplification, and interactions between more than one signal and among several signaling pathways.

The cell’s ability to respond to its environment is essential for normal development, cellular repair and immunity and is the basis of homeostasis. Errors in these pathways, caused by mutations that may result in constitutive expression or total inhibition of protein transcription, are responsible for such diseases as diabetes, autoimmune disorders and cancer.

Millipore is proud to announce the relaunch of Upstate’s Beadlyte cell signaling portfolio under the MILLIPLEX MAP brand – the new standard in multiplexing.

Using the Luminex xMAP platform, MILLIPLEX MAP Cell Signaling offers you the ability to investigate simultaneously the expression of intracellular total or phosphorylated proteins involved in multi-pathway signaling or focused in a specific pathway.

Simply choose the format that best meets your needs:

Comprehensive panels in a one-catalogue-number, all-in-one kit format
An ever-expanding portfolio of individual MAPmates
PathwayProfiler Service, providing access to the expertise of our BioMarker Services team

No matter which you choose, you will receive the advantage of speed combined with sensitivity. Likewise, you will benefit from our simplified ordering process and user-friendly protocols.