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Class	Ligand Type	GPCR Family	GPCR Target (Human unless noted)	NEW
A	non-peptide	Acetylcholine (muscarinic)	M1
A	non-peptide	Acetylcholine (muscarinic)	M2
A	non-peptide	Acetylcholine (muscarinic)	M3
A	non-peptide	Acetylcholine (muscarinic)	M4
A	non-peptide	Acetylcholine (muscarinic)	M5
A	non-peptide	Adenosine	A1
A	non-peptide	Adenosine	A2B
A	non-peptide	Adenosine	A3
A	non-peptide	Adrenergic	alpha1A
A	non-peptide	Adrenergic	alpha1B
A	non-peptide	Adrenergic	alpha1D
A	non-peptide	Adrenergic	alpha2A
A	non-peptide	Adrenergic	beta 1
A	non-peptide	Adrenergic	beta 2
A	non-peptide	Adrenergic	beta 3
A	non-peptide	alpha-Ketoglutarate	OXGR1 , GPR99 , GPR80
A	peptide	Anaphylotoxin	C3aR
A	peptide	Anaphylotoxin	C5aR
A	peptide	Angiotensin	AT1
A	peptide	Apelin	APJ
A	peptide	Bombesin	BB1
A	peptide	Bombesin	BB2
A	peptide	Bombesin	BB3
A	peptide	Bradykinin	B2
B	peptide	Calcitonin	CGRP1
C	non-peptide	Calcium sensor	CaS
A	non-peptide	Cannabinoid	CB1
A	non-peptide	Cannabinoid	CB2
A	peptide	Chemoattractant	ChemR23 / CMKLR1
A	peptide	Chemokine	CCR1
A	peptide	Chemokine	CCR10
A	peptide	Chemokine	CCR2B
A	peptide	Chemokine	CCR3
A	peptide	Chemokine	CCR4
A	peptide	Chemokine	CCR5, rhesus macaque
A	peptide	Chemokine	CCR6
A	peptide	Chemokine	CCR7
A	peptide	Chemokine	CCR8
A	peptide	Chemokine	CCR9
A	peptide	Chemokine	CX3CR1
A	peptide	Chemokine	CXCR1 / IL-8a
A	peptide	Chemokine	CXCR2 / IL-8b
A	peptide	Chemokine	CXCR3
A	peptide	Chemokine	CXCR4
A	peptide	Chemokine	CXCR5	New
A	peptide	Chemokine	CXCR6
A	peptide	Chemokine	XCR1 / GPR5
A	peptide	Cholecystokinin	CCK1 / CCKa
A	peptide	Cholecystokinin	CCK2 / CCKb
B	peptide	CRF Receptor	CRF1
B	peptide	CRF Receptor	CRF2
A	non-peptide	Dopamine	D1
A	non-peptide	Dopamine	D2L
A	non-peptide	Dopamine	D4	New
A	non-peptide	Dopamine	D5
A	peptide	Endothelin	ETA
A	peptide	Endothelin	ETB
A	non-peptide	Free Fatty Acid	FFA3 / GPR41
A	non-peptide	Free Fatty Acid	FFA2 / GPR43
C	non-peptide	GABAB	GABAB1b
A	peptide	Galanin	GAL1
A	peptide	Galanin	GAL2
A	peptide	Ghrelin	Ghrelin / GHSR-1a / growth hormone secretagogue receptor
B	peptide	Glucagon	GIP
B	peptide	Glucagon	GLP-1
B	peptide	Glucagon	GLP-2	New
B	peptide	Glucagon	glucagon / GCG
B	peptide	Glucagon	secretin receptor / SEC
C	non-peptide	Glutamate (metabotropic)	mGlu1	New
C	non-peptide	Glutamate (metabotropic)	mGlu2
A	peptide	Glycoprotein hormone	TSH / TSHR
A	peptide	GnRH	GnRH / LHRH
A	non-peptide	Histamine	H1
A	non-peptide	Histamine	H2
A	non-peptide	Histamine	H3
A	peptide	KiSS1-derived peptide	KiSS1 / GPR54
A	non-peptide	Leukotriene	BLT1
A	non-peptide	Leukotriene	CysLT1
A	non-peptide	Leukotriene	CysLT2
A	non-peptide	Lysophospholipid	LPA1 / EDG2
A	non-peptide	Lysophospholipid	LPA3 / EDG7
A	non-peptide	Lysophospholipid	LPA5 / GPR92
A	non-peptide	Lysophospholipid	S1P1 / EDG1
A	non-peptide	Lysophospholipid	S1P2 / EDG5
A	non-peptide	Lysophospholipid	S1P3 / EDG3
A	non-peptide	Lysophospholipid	S1P4 / EDG6
A	non-peptide	Lysophospholipid	S1P5 / EDG8
A	peptide	Mas-related gene	MRGX1 / MRGPRX1
A	peptide	Mas-related gene	MRGX2 / MRGPRX2
A	peptide	Mas-related gene	MRGPRD / MrgD
A	peptide	Melanin-concentrating hormone	MCHR1 / GPR24
A	peptide	Melanin-concentrating hormone	MCHR2
A	peptide	Melanocortin	MC2
A	peptide	Melanocortin	MC4
A	peptide	Melanocortin	MC5
A	peptide	Motilin	motilin receptor / MTLR / GPR38
A	peptide	Neuromedin U	NMU1
A	peptide	Neuromedin U	NMU2
A	peptide	Neuropeptide B/W	NPBW1 / GPR7
A	peptide	Neuropeptide Y	Y2
A	peptide	Neuropeptide Y	Y4
A	peptide	Neurotensin	NTR1 / NTS1
A	peptide	N-formylpeptide	FPR1
A	peptide	N-formylpeptide	FPRL1 / AXL / HM63
A	non-peptide	Nicotinic Acid	GPR109A
A	peptide	Opioid	Delta / OP1 / DOP / DOR
A	peptide	Opioid	Kappa / OP2 / KOP / KOR
A	peptide	Opioid	Mu / OP3 / MOP / MOR
A	peptide	Opioid	NOP / ORL1 / OP4
A	peptide	Orexin	OX1
A	peptide	Orexin	OX2
A	peptide	Oxytocin	OT
A	non-peptide	P2 / Purinergic (metabotropic)	P2Y1
A	non-peptide	P2 / Purinergic (metabotropic)	P2Y2
A	non-peptide	P2 / Purinergic (metabotropic)	P2Y4
A	non-peptide	P2 / Purinergic (metabotropic)	P2Y11
A	non-peptide	P2Y / Purinergic (metabotropic)	P2Y12	New
A	peptide	Peptide P518	GPR103 / QRFP
A	non-peptide	Platelet Activating Factor	PAF
A	peptide	Prokineticin	PK1 / PKR1
A	peptide	Prokineticin	PK2 / PKR2
A	peptide	Prolactin-releasing peptide	PRP / PrRP / GPR10
A	non-peptide	Prostanoid	DP
A	non-peptide	Prostanoid	EP1
A	non-peptide	Prostanoid	EP2
A	non-peptide	Prostanoid	EP3
A	non-peptide	Prostanoid	EP4
A	non-peptide	Prostanoid	FP
A	non-peptide	Prostanoid	IP1 / PGI2
A	non-peptide	Prostanoid	TP / TXA2 / PGH2
A	peptide	Protease-activated	Thrombin-activated PARs
A	peptide	Protease-activated	Trypsin-activated PARs
B	peptide	PTH receptor	PTH1
B	peptide	PTH receptor	PTH2
A	non-peptide	Serotonin	5-HT1A
A	non-peptide	Serotonin	5-HT2A
A	non-peptide	Serotonin	5-HT2B
A	non-peptide	Serotonin	5-HT2C
A	non-peptide	Serotonin	5-HT4	New
A	non-peptide	Serotonin	5-HT6
A	peptide	Somatostatin	sst2
A	peptide	Somatostatin	sst3
A	peptide	Somatostatin	sst4
A	peptide	Somatostatin	sst5
A	non-peptide	SPC/LPC /proton-sensor	GPR68/OGR1
A	non-peptide	Succinate	SUCNRI/GPR91	New
A	peptide	Tackykinin /neurokinin	NK1
A	peptide	Tackykinin /neurokinin	NK2
A	peptide	Tackykinin /neurokinin	NK3
A	peptide	TRH	TRH
A	peptide	Urotensin II	UT / UT1 / GPR14
A	peptide	Vasopressin	V1A
A	peptide	Vasopressin	V1B
A	peptide	Vasopressin	V2
B	peptide	VIP/PACAP	PAC1 long isoform / PACAP
B	peptide	VIP/PACAP	VPAC1 / VIP1
B	peptide	VIP/PACAP	VPAC2 / VIP2
A	non-peptide	Orphan	GPR39	New

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