PIProfiler

PI 3-Kinases in Cell Biology and Disease

Millipore's PIProfiler assay is ideal for lead identification and evaluation against human PI 3- kinase β, γ, and δ. The assay has been configured into a robust homogenous format utilizing homogenous time resolved fluorescence (HTRF®) technology.

Kinase Target Details

Biological & Disease Relevance

Subscription Agreements
Assay Protocols

Reference Data

Kinase Profiling Services Brochure

Kinase Target Details Biological & Disease Relevance Subscription Agreements	Assay Protocols Reference Data Kinase Profiling Services Brochure

PIProfiler Advantages

Robust

Assay utilizes Homogenous Time Resolved Fluorescence (HTRF) technology; yielding high quality, reliable data that avoids compound interference.

Flexibility

Assay options

- PI 3-kinase β, γ, or δ (human)
- PIP3/GRP1 PH domain interaction assay

ATP concentration (10M, 100 M, or KM ATP)
Number of compounds
Replicate number
Activity (% control)

Tiration of Wortmannin, LY-294002 and DOOO Against PI3-Kinase

PI 3-kinase activity was determined as described below in the presence of Wortmannin, LY-294002 or DOOO. The data are the mean ± SD of three independent titrations shown as percentage of the mean control value. The ATP used was 100 µM for PI 3-kinase γ and 200 µM for PI 3-kinase β and δ

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