AllostericProfiler Service
Historically, GPCR drug development has been focused on compounds that interact with the receptors’ orthosteric site; however, the orthosteric binding site can be highly conserved, making it extremely difficult to generate receptor-specific compounds.
Allosteric compounds are generating excitement because they can modulate receptor activity, allowing greater physiological control of receptor activation, and are predicted to be more selective and have a reduced potential for overdose.
Millipore’s AllostericProfiler service uses a functional readout to detect allosteric compound activity. AllostericProfiler is the first fully validated selectivity-profiling service capable of detecting a range of compound activities for over 155 GPCRs by using a unique two-addition methodology to detect of a wide variety of activities including agonist, positive allosteric modulator (PAM) and negative allosteric modulator (NAM) activity.
Easily identify off-target effects, including agonist, inhibitor, and allosteric modulator activities, using AllostericProfiler Services (click image to enlarge)
AllostericProfiler Service Highlights:
AllostericProfiler service offers all of the same advantages of GPCRProfiler services, plus:
- Unique screening method allows for detection of multiple activities including agonist, PAM and inhibitor activity.
- Access to our DART tool to visualize three different activities from a large profiling dataset
Get Started
- Log in to our Drug Discovery & Development Service Portal
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