Identification of PAMs by AllostericScreener Services. Positive allosteric modulators for M4 acetylcholine muscarinic receptors were readily detected by their ability to augment the response to a low concentration of acetylcholine.
With our AllostericScreener service, Millipore can also be your partner in identifying new positive allosteric modulators for your favorite GPCR.
Our AllostericScreener service screens compound libraries to identify new compounds having positive allosteric modulator (PAM) activity for a target of interest. AllostericScreener service employs an assay design that is similar, but slightly modified, to our standard GPCRProfiler services. This assay design can identify both agonist and PAM activities. Therefore, you can discriminate hits that either activate the receptor directly, modulate the receptor’s activity or those that have a mixture of these activities.
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