PrecisION Recombinant Ion Channel Cell Lines
Choose from our expanding portfolio of PrecisION cell lines. These ion channel cell lines have been pharmacologically and functionally validated—using both conventional and automated electrophysiology—and are stable for over 25 cell passages.
(Left) PatchXpress Nav1.5 assay measuring
‘resting-state’ block.
Concentration response curves with three reference compounds. IC50 values, obtained from a logistic fit of the data, were 71.9 ± 30 μM, 69.4 ± 24 μM and 14 ± 2 μM for lamotrigine, mexiletine and flecainide respectively.
PrecisION Cell Lines Feature:
- Superior vector technologies for optimum stability, expression and uniform current
- Performance optimization for automated patch clamp electrophysiology
- Excellent performance in conventional patch clamp electrophysiology
- Comprehensive characterization of biophysical and pharmacological properties
- Additional lines in development—custom cell line generation service also available
- Comprehensive technical support
Including:
- Potassium Family Ion Channel Cell Lines
- Sodium Family Ion Channel Cell Lines
- Hyperpolarized Family Ion Channel Cell Lines
- TRP Family Ion Channel Cell Lines
- Calcium Family Ion Channel Cell Lines
- Ligand-Gated Family Ion Channel Cell Lines
- Chloride Family Ion Channel Cell Lines
