Beyond hERG Screening.
Multiple ion channels regulate cardiac action potential – CardiacProfiler Services can assess the effect of compounds on each of these and more.
CardiacProfiler Service
Gain a broader insight into cardiac safety with earlier profiling of new chemical entities at throughputs that are more appropriate for lead discovery and optimization. CardiacProfiler is a comprehensive cardiac safety panel that includes each of the key cardiac channels, providing a robust, cost-effective alternative to complement more complex and low throughput assay formats. Our CardiacProfiler service is fully flexible, enabling you to submit any numbers of compounds against any of the CardiacProfiler ion channels.
Advantages of CardiacProfiler Services:
- Only provider licensed to offer an L-type calcium channel service for liability testing
- Validated cell lines and protocols ensure high-quality, reproducible results you can trust
- A plate-based APC platform offers affordable, 1-4 week turnaround
- A cost-effective alternative to complex and specialized action potential duration assays
- Flexible services can be tailored to meet requirements for throughput, data quality and cost
Cardiotoxicity can be caused by more ion channels than hERG.
Excitation and relaxation of cardiac muscle is regulated by a variety of different ion channels. Some of these channels are genetically linked with long QT syndrome, suggesting that modulation by drugs could also produce life-threatening arrhythmias independently of hERG. Conversely, a number of relatively potent hERG channel blockers do not induce TdP. Many of these drugs (e.g. verapamil, amiodarone) have mixed channel blocking action which may ameliorate the effects of hERG blockade. Thus, hERG screening alone may be insufficient to flag potential cardiac liability, and abandoning promising compounds based on hERG blockade alone may be a costly mistake.
Ion Channels Included in CardiacProfiler Panel Services Include:
hERG, hNav1.5, hKCNQ1/hminK, human L-type Calcium, hKv4.3/hKChIP2, hKv1.5, hKir2.1, hHCN4
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