FlexLab Kinase and Phosphatase Services
Our FlexLab provides you with experience, expertise and the flexibility you require to expand your screening and profiling capacity where you need it. We offer custom protein production for kinases, phosphatases and protein substrates. Email drugdiscovery@millipore.com to take advantage of FlexLab Services today.
FlexLab Kinase and Phosphatase Services Highlights:
- Custom screening of wild-type vs. mutant kinases—find out whether a particular mutation activates or inactivates your enzyme
- Development of direct kinase assays
- Ki analysis: Determination of IC50 dependence on ATP concentration
- Slow off-rate measurement: Compound dilution assay
- Slow on-rate measurement: Pre-incubation of compounds
- Substrate screening for phosphatases and kinases
- Fluorescence effects of compounds in HTRF assays
- Effects of different divalent cations or other buffer components
- Activator screening
- Custom expression and purification work
- Autophosphorylation assays
- Type II inhibitor binding
Leading-edge Technologies:
- Radiometric assays
- Validated protein kinase HTRF assays
- Phosphatase assays - DiFMUP
- PI3 kinase HTRF assays
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