Featured New Assays
- B-Raf Wild-type cascade assay
- B-Raf V600E cascade assay
- LRRK2 assay
- JAK1 assay
- TYK2 assay
- Wee1 assay
- PAK1 assay
- IKKε assay
- CLK4 assay
KinaseProfiler™
KinaseProfiler™ provides the industry's fastest turnaround, design flexibility, and best-in-class catalytic assay to accelerate your discoveries. Utilizing advances in EMD Millipore screening technology and Upstate® kinases, we offer an extensive and disease-relevant panel of protein kinases, lipid kinases, and kinase mutants. Our gold-standard functional assays, consultative scientific support, and flexible service offerings have made us “the most preferred and most used kinase service provider in the industry” (Kinase Screening & Profiling Trends, HTStec Ltd 2010).
1-Week Turnaround Time Guarantee
Available for most projects, including KinaseProfiler™, IC50 Profiler™, and PhosphataseProfiler™, the guarantee promises the delivery of your profiling data within one week of activation. Eligible projects are activated each Friday and data reports are delivered on or before the following Friday. Submit a quote request or contact our project management team to get started.
KinaseProfiler™ Data Displayed With DART™
Visualization Tool.
Red and green markers indicate targets strongly inhibited or uninhibited, respectively, by the selected compound.
Consultative and Flexible
Our PhD Project Managers and scientists are available to you for detailed consultation at all stages, from concept to reporting. We provide a high level of flexibility in study design including:
- Choice and number of kinases tested
- Number of replicates
- Number of compound concentrations
- ATP concentrations – Km, 10 µM, or custom
- Compound shipping format – in DMSO or as solid, vials or 96-well plates
- Reserved assay slots to allow a steady flow of compounds for the fastest possible throughput
- All results subjected to strict QC standards
- Confidentiality guaranteed
Ordering and Service Details
Visualization of selectivity and potency of three p38 inhibitors (top) and three JNK inhibitors (bottom) distributed around 234 kinases. Lines stretching to the perimeter indicate interactions having the highest potency.
NEW: A Chemogenomic Map for Kinase Signaling Research
Let us help you investigate structure, activity, and off-target effects across the kinome. We’ve screened a well-defined collection of 158 kinase inhibitors for inhibitory activity against 234 active human protein kinases, representing all branches of the kinome tree. This rich dataset is now available in our Biochemical Journal publication.
Highlights:
- Selectivity and potency visualization
- Pairwise structure and activity similarity
- Novel observations to support polypharmacology strategies
This study was featured in a presentation and poster at CHI Next-Gen Kinase Inhibitors 2012.