Research Spotlight: A broad activity screen

A broad kinase activity screen supports a chemogenomic map for kinase signaling research, Gao et al, Biochemical Journal, 2013.

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Kevin J. Harvey, Ph.D.
Senior Manager,
Research and Development,
EMD Millipore

Kinases and Phosphatases in
Drug Discovery

Phosphate groups are post-translational modifications that regulate many disease states, including cancer, neurodegenerative diseases, diabetes, pain, autoimmunity, and cardiovascular diseases. As a result, the responsible modifying enzymes – kinases and phosphatases – have been a focus of therapeutic modulation, with the hopes of improving human health.
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