Ubiqutination Enzymes and Substrates
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Product listing:
EMD Millipore has removed the complexity of ubiquitination by providing functionally validated ubiquitin cascades, making the pathway readily accessible for research and drug discovery. All of our enzymes are available in quantities sufficient for routine testing, as well as high throughput screening.


Simplifying Ubiquitination Drug Discovery
We have developed the following proteins and protocols needed for you to get started with 20+ biological pathways. Download our Assay Protocol Guide for details and browse our ubiquitin product listing.

E3 Ligase or Complex Compatible E2 Conjugating Enzymes Compatible Substrates
XIAP - Coming soon UbcH4 Smac/DIABLO
MuRF1 – New! UbcH5c Cardiac Troponin I
VHL Penta-complex
  • UbcH4
  • UbcH5a
  • UbcH5c
HIF-1α
MDM2/CK1δ
  • UbcH4
  • UbcH5c
p53
MDM2
  • UbcH4
  • UbcH5c
auto-ubiquitination
Parkin; Parkin(myc)
  • UbcH6
  • UbcH7
  • p38/JTV-1
  • auto-ubiquitination
c-Cbl UbcH4
  • Kit
  • Src
CHIP; CHIP(myc) UbcH13/Uev1A
  • Hsp70
  • p53
  • auto-ubiquitination
SCF-βTrCP1 Penta-complex
  • UbcH3
  • UbcH4
  • IκBα
  • β-Catenin
SCF-Fbw7 Quad-complex
  • UbcH3
  • UbcH5a
Cyclin E1 Complex
SCF-Skp2/Cks1 Penta-complex UbcH3 P27 Complex