Discover how your compound is affecting signal transduction pathways
Many important drug target classes either trigger signal transduction (e.g., cell surface receptors like GPCRs and Receptor Tyrosine Kinases) or directly participate in the transduction of the signal (e.g., intracellular kinases like Erk kinase). Signaling pathway analysis enables you to identify how signaling nodes, signal redundancy and feedback loops may affect the desired activity of a compound inhibitor, providing complementary data to target-specific profiling and biochemical assays.
Unique, Biologically Relevant Pathway Analysis
Unlike other pathway analysis services that involve engineered, reporter cell lines or the use of large amounts of sample lysates, Millipore’s SignalProfiler Services provides analysis on a cell or tissue that is appropriate for your research interests, thus bridging a gap between a compound’s in vitro biochemical activity with its more relevant cellular activity.
Multiplexed immunodetection of phosphorylated proteins using Luminex xMAP fluorescent-coded beads. Learn more about the technology here.
Benefits of SignalProfiler™
- Partially- or fully-outsourced service options available – EMD Millipore does all of the cell work
- Multiplexed analysis of key pathways including
- receptor tyrosine kinase (RTK) pathways
- MAPK pathway
- Akt/mTOR pathway
- p38/SAP pathway
- Src kinase pathway
- Utilizes Millipore’s MILLIPLEX MAPmates™ immunoassays which are based on Luminex® xMAP® technology - the most trusted platform for multiplex protein quantification.
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