Neurobiology
The differentiated central nervous system is a complex environment composed of 100 billion neurons and at least that many glial support cells. With potentially thousands of synaptic contacts on each neuron, the fine-structure circuitry reflects the trillions of neural connections that underly our amazing brain function. This amazing diversity of neural architecture and function must organize relatively quickly in developmental time, be maintained through adulthood, and yet be surpisingly changeable to accommodate learning. Indeed, the maturation and integration of neural stem cells, the outgrowth and dynamics of changing synapses, and the function and dysfunction of neural processes in the face of damage and disease are key areas in neuroscience research today.
Millipore’s Chemicon® line of neuroscience antibodies, proteins and kits comprise a broad line of well-characterized tools for the study of developmental, synaptic, and degenerative mechanisms in the nervous system. Millipore’s immunodetection products provide invaluable assistance in the identification, cellular and subcellular localization and measurement of defining structures in most cell types comprising the developing and differentiated nervous system.
Products for Neurobiology
Verberate neuron-specific nuclear protein or NeuN (Neuronal Nuclel). Cat No.MAB377 reacts with NeuN, which is found in most neuronal cell types throughout the nervous system of mice including cerebellum, cerebral cortex, hippocampus, thalamus, spinal cord and neurons in the peripheral nervous system including dorsal root ganglia, sympathetic chain ganglia, and enteric ganglia. The immunohistochemical staining is primarily in the nucleus of the neurons with lighter staining in the cyptoplasm. The few cell types not reactive to Cat. No. MAB377 include Purkinje, mitral, and photoreceptor cells. Developmentally, immunoreactivity is first observed shortly after neurons have become postmitotic, no staining has been observed in proliferative zones. The antibody is an excellent marker for neurons in primary cultures and in retinoic acid-stimulated P19 cells. It is also useful for identifying neurons in transplants. Immunogen: Purified cell nuclei from mouse brain.
Mouse anti-NeuN (Cat. No. MAB377) and Rabbit anti-substance P Receptor (Cat. No. AB5060) staining of normal rat hippocampus. | Rabbit anti-Tyrosine Hydroxylase (Cat. No. AB152) staining of rat brain stem. | Mouse anti-NeuN (Cat. No. MAB377) Immunolocalization of NeuNim mouse corpus collosum (cortex). |
 | ||
Rabbit anti-Tyroxine Hydroxylase (Cat. No Ab152) localization of tyrosine hydroyiase in culture of primary neurons. | |
Neue Produkte
- New Product Guide to Millipore’s Antibodies and Kits - Free reference book for immunoassay and protein research application
- New OxyELISA™ Kit Provides Quantitative Measure of Oxidative Stress - High throughput kit improves specificity and shortens assay time
- PureProteome Nickel Magnetic Beads from Millipore
- SNAP i.d.™ Protein Detektions-System
Ausgewählte Produkte
- Catch and Release Reversible Immunoprecipitation system
- Protein G Agarose Fast Flow
- Immobilon-FL Transfer Membrane
- Immobilon Chemiluminescent HRP Substrate
- Amicon Ultra
- Ultrafree MC
- Anti-NeuN, Marker for Post-Mitotic Neurons
- Anti-Tyrosine Hydroxylase
- Anti-Actin (Clone C4)
- Anti-Cytokeratin 5, 6, Clone D5/16B4