Map Key
Generic Enzyme
Generic kinase
Protein kinase
Lipid kinase
Generic phosphatase
Protein phosphatase
Lipid phosphatase
Generic phospholipase
Generic protease
Metalloprotease
G-alpha
RAS - superfamily
G beta/gamma
Regulators (GDI, GAP, GEF)
Generic channel
Ligand-gated channel
Voltage-gated channel
Transporter
Normal process
Pathological process
Positive effect
Negative effect
Unspecified effect
Technical link
Disrupts in disease
Emerges in disease
Enhances in disease
Weakens in disease
Organsim specific interaction

Generic binding protein
Receptor ligand
Cell membrane glycoprotein
Transcription factor
DNA
RNA
Compound
Inorganic ion
Predicted metabolite or user's structure
Reaction
Generic receptor
GPCR
Receptors with enzyme activity
Mitochondria
EPR
Golgi
Nucleus
Lysosome
Peroxisome
Cytoplasm
Extracellular

Normal process
Pathological process
Binding
Cleavage
Covalent modifications
Phosphorylation
Dephosphorylation
Transformation
Transport
Catalysis
Transcription regulation
MicroRNA binding
Competition
Influence on expression
Unspecified interactions
Pharmacological effect
Toxic effect
Group relation
Complex subunit
Similarity reaction
A complex or a group
Organism specific object

Cell adhesion Gap junctions


Log In to Post A Comment

Cell adhesion Gap junctions

Gap junctions

Gap junction channels are intercellular channels that allow passage of ions, such asK(+) and Na(+), and other small molecules between neighboring cells. Thesechannels are formed from two multimeric subunits called hemichannels, or connexons, thatreside in plasma membranes of two closely opposed cells.

Connexons are composed of six transmembrane protein subunits called Connexins[1]. The double membrane channel, or gap junction, is generated directly andcouples the cytoplasms of the interacting cells. This leads to integration andco-ordination of the cellular metabolism, signaling and function, e.g.,secretion orcontraction in cell assemblies [2].

Interactions of Connexins with Zona occludens proteins ( ZO-1,ZO-2 and ZO-3 ) couple gap junction channels with the tight junctioncomponents, such as Occludin, and with cytoskeletal elements, such asActin filaments [3].

Connexins 43 and 36 can anchor Microtubules (consisting of theAlpha/Beta-tubulin dimers) to gap junctions and thereby can affect the propertiesof microtubules in contacted cells [4], [5].