Cell adhesion Cadherin-mediated cell adhesion
Cadherin-mediated cell adhesion Cadherins are calcium-dependent homophilic cell adhesion proteins essential fortissue organization. Establishment of stable cell-cell adhesion depends on association ofclassical Cadherins with Catenins, which links cell surface adhesion andrecognition to both Actin cytoskeleton and cell signaling pathways. Catenin(cadherin-associated protein), beta 1 (Beta-catenin) binds with high affinity tothe distal Cadherin cytoplasmic tail and, in turn, recruits Catenin(cadherin-associated protein), alpha 1, 102kDa ( Alpha-catenin ) to the complex.Alpha-catenin binds to Actin filaments directly and can also associate witha range of other actin-binding proteins such as Myeloid/lymphoid or mixed-lineageleukemia; translocated to, 4 ( AF-6 ) and Formin. In contrast, Catenindelta 1 ( p120-catenin ) binds directly to Cadherin independently of theother catenins. Cadherin-Catenins complex can further interact with arange of signaling molecules which participate in either cellular signaling or control ofcytoskeletal dynamics . Stability of the Cadherin/Catenins complex and thereby the integrity of adherent junction is controlled byphosphorylation/ dephosphorylation. Phosphorylation of Beta-catenin by receptor-and non-receptor-types tyrosine kinases results in dissociation of Alpha-cateninfrom Beta-catenin with concomitant loss of cadherin adhesion, whereas tyrosinephosphatases ensure or restore the integrity of Cadherin -mediated adhesions.