Map Key
Generic Enzyme
Generic kinase
Protein kinase
Lipid kinase
Generic phosphatase
Protein phosphatase
Lipid phosphatase
Generic phospholipase
Generic protease
Metalloprotease
G-alpha
RAS - superfamily
G beta/gamma
Regulators (GDI, GAP, GEF)
Generic channel
Ligand-gated channel
Voltage-gated channel
Transporter
Normal process
Pathological process
Positive effect
Negative effect
Unspecified effect
Technical link
Disrupts in disease
Emerges in disease
Enhances in disease
Weakens in disease
Organsim specific interaction

Generic binding protein
Receptor ligand
Cell membrane glycoprotein
Transcription factor
DNA
RNA
Compound
Inorganic ion
Predicted metabolite or user's structure
Reaction
Generic receptor
GPCR
Receptors with enzyme activity
Mitochondria
EPR
Golgi
Nucleus
Lysosome
Peroxisome
Cytoplasm
Extracellular

Normal process
Pathological process
Binding
Cleavage
Covalent modifications
Phosphorylation
Dephosphorylation
Transformation
Transport
Catalysis
Transcription regulation
MicroRNA binding
Competition
Influence on expression
Unspecified interactions
Pharmacological effect
Toxic effect
Group relation
Complex subunit
Similarity reaction
A complex or a group
Organism specific object

Cell adhesion Cadherin-mediated cell adhesion


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Cell adhesion Cadherin-mediated cell adhesion

Cadherin-mediated cell adhesion

Cadherins are calcium-dependent homophilic cell adhesion proteins essential fortissue organization. Establishment of stable cell-cell adhesion depends on association ofclassical Cadherins with Catenins, which links cell surface adhesion andrecognition to both Actin cytoskeleton and cell signaling pathways. Catenin(cadherin-associated protein), beta 1 (Beta-catenin) binds with high affinity tothe distal Cadherin cytoplasmic tail and, in turn, recruits Catenin(cadherin-associated protein), alpha 1, 102kDa ( Alpha-catenin ) to the complex.Alpha-catenin binds to Actin filaments directly and can also associate witha range of other actin-binding proteins such as Myeloid/lymphoid or mixed-lineageleukemia; translocated to, 4 ( AF-6 ) and Formin. In contrast, Catenindelta 1 ( p120-catenin ) binds directly to Cadherin independently of theother catenins. Cadherin-Catenins complex can further interact with arange of signaling molecules which participate in either cellular signaling or control ofcytoskeletal dynamics [1]. Stability of the Cadherin/Catenins complex and thereby the integrity of adherent junction is controlled byphosphorylation/ dephosphorylation. Phosphorylation of Beta-catenin by receptor-and non-receptor-types tyrosine kinases results in dissociation of Alpha-cateninfrom Beta-catenin with concomitant loss of cadherin adhesion, whereas tyrosinephosphatases ensure or restore the integrity of Cadherin -mediated adhesions[2].