Map Key
Generic Enzyme
Generic kinase
Protein kinase
Lipid kinase
Generic phosphatase
Protein phosphatase
Lipid phosphatase
Generic phospholipase
Generic protease
Metalloprotease
G-alpha
RAS - superfamily
G beta/gamma
Regulators (GDI, GAP, GEF)
Generic channel
Ligand-gated channel
Voltage-gated channel
Transporter
Normal process
Pathological process
Positive effect
Negative effect
Unspecified effect
Technical link
Disrupts in disease
Emerges in disease
Enhances in disease
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Organsim specific interaction

Generic binding protein
Receptor ligand
Cell membrane glycoprotein
Transcription factor
DNA
RNA
Compound
Inorganic ion
Predicted metabolite or user's structure
Reaction
Generic receptor
GPCR
Receptors with enzyme activity
Mitochondria
EPR
Golgi
Nucleus
Lysosome
Peroxisome
Cytoplasm
Extracellular

Normal process
Pathological process
Binding
Cleavage
Covalent modifications
Phosphorylation
Dephosphorylation
Transformation
Transport
Catalysis
Transcription regulation
MicroRNA binding
Competition
Influence on expression
Unspecified interactions
Pharmacological effect
Toxic effect
Group relation
Complex subunit
Similarity reaction
A complex or a group
Organism specific object

Dichloroethylene metabolism


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Dichloroethylene metabolism

Dichloroethylene metabolism.

Dichloroethylene, a chemical used in the manufacturing of plastics, can causepulmonary and hepatocellular injury. Mechanism of Dichloroethylene-induced injuryinvolves cytochrome P-450-catalyzed metabolism of this compound resulting in formation ofreactive intermediates, such as Dichloroacetaldehyde, Dichloroethyleneepoxide, and 2-Chloroacetyl chloride, that bind covalently to bioactivemacromolecules in liver. Cytochrome P450, family 2, subfamily F, polypeptide 1 (CYP2F1 ) and Cytochrome P450, family 2, subfamily E, polypeptide 1 ( CYP2E1) are involved in oxidative metabolism of Dichloroethylene [1],[2], [3], [4]. Detoxification ofDichloroethylene is primarily dependent upon availability of reduced glutathionefor conjugation. Secondary metabolites are produced as the result of further conjugationreactions that result in the synthesis of S-(2,2-Dichloro-1-hydroxy)ethylglutathione, 2-(S-Glutathionyl)acetyl glutathione, and 2-Chloroacetylglutathione. Conjugation with glutathione catalyzed by Glutathione S-transferase A2 ( GSTA2 ) [5], [6], [1].