Dichloroethylene metabolism. Dichloroethylene, a chemical used in the manufacturing of plastics, can causepulmonary and hepatocellular injury. Mechanism of Dichloroethylene-induced injuryinvolves cytochrome P-450-catalyzed metabolism of this compound resulting in formation ofreactive intermediates, such as Dichloroacetaldehyde, Dichloroethyleneepoxide, and 2-Chloroacetyl chloride, that bind covalently to bioactivemacromolecules in liver. Cytochrome P450, family 2, subfamily F, polypeptide 1 (CYP2F1 ) and Cytochrome P450, family 2, subfamily E, polypeptide 1 ( CYP2E1) are involved in oxidative metabolism of Dichloroethylene ,, , . Detoxification ofDichloroethylene is primarily dependent upon availability of reduced glutathionefor conjugation. Secondary metabolites are produced as the result of further conjugationreactions that result in the synthesis of S-(2,2-Dichloro-1-hydroxy)ethylglutathione, 2-(S-Glutathionyl)acetyl glutathione, and 2-Chloroacetylglutathione. Conjugation with glutathione catalyzed by Glutathione S-transferase A2 ( GSTA2 ) , , .