Selected targets of ESR1
Selected targets of ESR1 Estrogen receptor 1 ( ESR1 ) gene encodes an estrogen receptor, aligand-activated transcription factor composed of several domains important for hormonebinding, DNA binding, and activation of transcription . ESR1 isinvolved in regulation of many normal processes, such as development, reproduction,apoptosis, neurophysiologic processes , , ,  and pathological processes, such as including breast cancer,endometrial cancer, and osteoporosis , . ESR1 is essential for sexual development, reproductive function and organmorphogenesis. It regulates transcription of some developmental signal proteins: SRY (sexdetermining region Y)-box 3 and 9 ( SOX3 and SOX9 ) ,, Forkhead box A1 ( HNF3-alpha ) , Bonemorphogenetic protein 6 ( BMP6 ) . ESR1 play important role in metabolism regulation influencing on transcriptionof many enzymes: Alpha-methylacyl-CoA racemase ( AMACR ) , WWdomain containing oxidoreductase ( WWOX ) ,3-hydroxy-3-methylglutaryl-Coenzyme A reductase ( HMDH )  etal. Many functions of ESR1 are realized via regulation of channels and transportersin different tissues. For example, it stimulates transcription of Solute carrier family 9(sodium/hydrogen exchanger) member 1 ( SLC9A1 ), Glutamate receptor ionotropic,kainate 4 ( Grik4 ) , Aquaporin 5 , Solutecarrier family 2 (facilitated glucose transporter) member 1 ( GLUT1 )  and others.