Selected targets of C/EBPalpha
Selected targets of C/EBPalpha
The CCAAT/enhancer binding protein alpha ( C/EBPalpha ) is the member of afamily of related leucine zipper transcription factors that play important roles inmyeloid differentiation. Targeted inactivation of C/EBPalpha in mice demonstratesits importance in the proper development and function of liver, adipose tissue, lung andhaematopoietic tissues. C/EBPalpha is highly expressed in these differentiatedtissues where it controls differentiation-dependent gene expression and inhibits cellproliferation [1].
One of most important role of C/EBPalpha is in hematopoesis. It activatestranscription of Colony stimulating factor 3 receptor ( G-CSF receptor ) [2] and Colony stimulating factor 2 receptor alpha low-affinity ( CSF2RA )[3]. In addition, C/EBPalpha participates in immunological andinflammatory signaling regulation by activating transcription of such gene asAlpha-defensin [4], Cathepsin G [5], Elastase 2neutrophil ( Leukocyte elastase ) [6].
C/EBPalpha is essential for initiating or sustaining several metabolicprocesses during the perinatal and postnatal periods [7]. For example, itactivates transcription of some fatty acid and cholesterol transporters, such as Fattyacid binding protein 4 adipocyte ( A-FABP ) [8], Cholesteryl estertransfer protein, plasma ( CETP ) [9], Apolipoprotein B ( APOB) [10].
In addition, C/EBPalpha plays important role in insulin signaling and adipocytedifferentiation [11], [12], e.g., via stimulation oftranscription of Resistin [13], Adiponectin C1Q and collagen domaincontaining ( Adiponectin ) [14], Solute carrier family 2 member 2 (GLUT2 ) [15], A-FABP [8].
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