Selected targets of C/EBPalpha
Selected targets of C/EBPalpha The CCAAT/enhancer binding protein alpha ( C/EBPalpha ) is the member of afamily of related leucine zipper transcription factors that play important roles inmyeloid differentiation. Targeted inactivation of C/EBPalpha in mice demonstratesits importance in the proper development and function of liver, adipose tissue, lung andhaematopoietic tissues. C/EBPalpha is highly expressed in these differentiatedtissues where it controls differentiation-dependent gene expression and inhibits cellproliferation . One of most important role of C/EBPalpha is in hematopoesis. It activatestranscription of Colony stimulating factor 3 receptor ( G-CSF receptor )  and Colony stimulating factor 2 receptor alpha low-affinity ( CSF2RA ). In addition, C/EBPalpha participates in immunological andinflammatory signaling regulation by activating transcription of such gene asAlpha-defensin , Cathepsin G , Elastase 2neutrophil ( Leukocyte elastase ) . C/EBPalpha is essential for initiating or sustaining several metabolicprocesses during the perinatal and postnatal periods . For example, itactivates transcription of some fatty acid and cholesterol transporters, such as Fattyacid binding protein 4 adipocyte ( A-FABP ) , Cholesteryl estertransfer protein, plasma ( CETP ) , Apolipoprotein B ( APOB) . In addition, C/EBPalpha plays important role in insulin signaling and adipocytedifferentiation , , e.g., via stimulation oftranscription of Resistin , Adiponectin C1Q and collagen domaincontaining ( Adiponectin ) , Solute carrier family 2 member 2 (GLUT2 ) , A-FABP .