Map Key
Generic Enzyme
Generic kinase
Protein kinase
Lipid kinase
Generic phosphatase
Protein phosphatase
Lipid phosphatase
Generic phospholipase
Generic protease
Metalloprotease
G-alpha
RAS - superfamily
G beta/gamma
Regulators (GDI, GAP, GEF)
Generic channel
Ligand-gated channel
Voltage-gated channel
Transporter
Normal process
Pathological process
Positive effect
Negative effect
Unspecified effect
Technical link
Disrupts in disease
Emerges in disease
Enhances in disease
Weakens in disease
Organsim specific interaction

Generic binding protein
Receptor ligand
Cell membrane glycoprotein
Transcription factor
DNA
RNA
Compound
Inorganic ion
Predicted metabolite or user's structure
Reaction
Generic receptor
GPCR
Receptors with enzyme activity
Mitochondria
EPR
Golgi
Nucleus
Lysosome
Peroxisome
Cytoplasm
Extracellular

Normal process
Pathological process
Binding
Cleavage
Covalent modifications
Phosphorylation
Dephosphorylation
Transformation
Transport
Catalysis
Transcription regulation
MicroRNA binding
Competition
Influence on expression
Unspecified interactions
Pharmacological effect
Toxic effect
Group relation
Complex subunit
Similarity reaction
A complex or a group
Organism specific object

Selected targets of C/EBPalpha


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Selected targets of C/EBPalpha

Selected targets of C/EBPalpha

The CCAAT/enhancer binding protein alpha ( C/EBPalpha ) is the member of afamily of related leucine zipper transcription factors that play important roles inmyeloid differentiation. Targeted inactivation of C/EBPalpha in mice demonstratesits importance in the proper development and function of liver, adipose tissue, lung andhaematopoietic tissues. C/EBPalpha is highly expressed in these differentiatedtissues where it controls differentiation-dependent gene expression and inhibits cellproliferation [1].

One of most important role of C/EBPalpha is in hematopoesis. It activatestranscription of Colony stimulating factor 3 receptor ( G-CSF receptor ) [2] and Colony stimulating factor 2 receptor alpha low-affinity ( CSF2RA )[3]. In addition, C/EBPalpha participates in immunological andinflammatory signaling regulation by activating transcription of such gene asAlpha-defensin [4], Cathepsin G [5], Elastase 2neutrophil ( Leukocyte elastase ) [6].

C/EBPalpha is essential for initiating or sustaining several metabolicprocesses during the perinatal and postnatal periods [7]. For example, itactivates transcription of some fatty acid and cholesterol transporters, such as Fattyacid binding protein 4 adipocyte ( A-FABP ) [8], Cholesteryl estertransfer protein, plasma ( CETP ) [9], Apolipoprotein B ( APOB) [10].

In addition, C/EBPalpha plays important role in insulin signaling and adipocytedifferentiation [11], [12], e.g., via stimulation oftranscription of Resistin [13], Adiponectin C1Q and collagen domaincontaining ( Adiponectin ) [14], Solute carrier family 2 member 2 (GLUT2 ) [15], A-FABP [8].