Selected targets of C/EBPbeta
Selected targets of C/EBPbeta The CCAAT/enhancer-binding protein beta ( C/EBPbeta ) is themember of a family of related leucine zipper transcription factors that play importantroles in regulation of differentiation and inflammatory processes in adipocytes, liver,brain and other tissues , , , . C/EBPbeta participates in immunological and inflammatory signalingregulation leading to the activation of transcription of a number of proteins, forexample of Elastase 2 neutrophil ( Leukocyte elastase ) , Chemokine(C-C motif) ligand 3 ( MIP-1-alpha ) , S100 calcium bindingprotein A8 ( Calgranulin A ) , and Macrophage scavenger receptor (108p22/MSR1(CD204) ) . C/EBPbeta is essential for insulin signaling and adipocyte differentiation. Forexample, it activates transcription of Resistin, Adiponectin C1Q and collagendomain containing ( Adiponectin ) , Solute carrier family 2 member2 ( GLUT2 ) , and Fatty acid binding protein 4 adipocyte (A-FABP ) . In addition, C/EBPbeta activates transcription of some fatty acid andcholesterol transporters: A-FABP , Cholesteryl ester transferprotein, plasma ( CETP ) , Apolipoprotein B ( APOB ) . Role of C/EBPbeta in brain development and inflammation may be explained bystimulation transcription of Neurogenic differentiation 6 ( NEUROD6 ) , and Tachykinin precursor 1 ( Substance P ) .