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Immune response Antigen presentation by MHC class II


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Immune response Antigen presentation by MHC class II

Antigen presentation by MHC class II

Antigen processing and presentation is the process by which antigen-presentingcells express antigen on cell surface in a form recognizable by lymphocytes.Antigen processing consists of protein fragmentation (proteolysis), association offragments with MHC (major histocompatibility complex) and expression of peptide-MHCcomplex at cell surface where they can be recognized by T cell receptor ( TCR).

Expression of MHC genes is constitutively activated during development in professionalantigen-presenting cells, such as B cells, dendritic cells, and macrophages.

There are two classes of MHC molecules, MHC class I and MHC class II. MHCclass II proteins specialize in presentation of exogenous antigens to TCR of CD4+T-cells.

Exogenous proteins are endocytosed and degraded by acidic proteases ( Legumain, Cathepsin L and Cathepsin S ) resident within endosomes and lysosomes[1]. Gamma-interferon-inducible lysosomal thiol reductase IP-30facilitates unfolding of endocytosed antigens in MHC class II -containingcompartments by enzymatic cleavage of disulfide bonds [2].

MHC class II molecules are assembled in the endoplasmic reticulum by thechaperone CD74, which directs these complexes to the endosomal compartments.Processing of CD74 includes its initial cleavage by Legumain, followed bylate stage cleavage by Cathepsin S and Cathepsin L [3], [1].

HLA-DM, a vesicle membrane protein, mediates CD74 removal (its lastsmall fragment) from MHC class II polypeptides, and then MHC class IImolecules are capable to bind antigens. MHC class II - Antigen complex isthen transported to cell surface for presentation to CD4+ T-cells [4].