Map Key
Generic Enzyme
Generic kinase
Protein kinase
Lipid kinase
Generic phosphatase
Protein phosphatase
Lipid phosphatase
Generic phospholipase
Generic protease
Metalloprotease
G-alpha
RAS - superfamily
G beta/gamma
Regulators (GDI, GAP, GEF)
Generic channel
Ligand-gated channel
Voltage-gated channel
Transporter
Normal process
Pathological process
Positive effect
Negative effect
Unspecified effect
Technical link
Disrupts in disease
Emerges in disease
Enhances in disease
Weakens in disease
Organsim specific interaction

Generic binding protein
Receptor ligand
Cell membrane glycoprotein
Transcription factor
DNA
RNA
Compound
Inorganic ion
Predicted metabolite or user's structure
Reaction
Generic receptor
GPCR
Receptors with enzyme activity
Mitochondria
EPR
Golgi
Nucleus
Lysosome
Peroxisome
Cytoplasm
Extracellular

Normal process
Pathological process
Binding
Cleavage
Covalent modifications
Phosphorylation
Dephosphorylation
Transformation
Transport
Catalysis
Transcription regulation
MicroRNA binding
Competition
Influence on expression
Unspecified interactions
Pharmacological effect
Toxic effect
Group relation
Complex subunit
Similarity reaction
A complex or a group
Organism specific object

Selected targets of HNF1


Log In to Post A Comment

Selected targets of HNF1

Selected targets of HNF1

Two Hepatocyte nuclear factors 1 (HNF1), HNF1-alph a andHNF1-beta, share strong homology in the dimerization domain and DNA-binding domain[1]. Both factors are expressed in polarized epithelia of different organs,including the liver, digestive tract, pancreas, and kidney. HNF1-alpha is notexpressed in lung, whereas HNF1-beta is not expressed in liver. In other organs,HNF1-alpha and HNF1-beta are more or less equally expressed. A significantdifference between HNF1-alpha and HNF1-beta is at the onset of theirexpression during embryonic development [1].

HNF1-alpha plays very important role in liver and metabolic processes. It isinvolved in the regulation of a large set of hepatic genes, including Albumin[2], [3], Cytochrome P450 family 2 subfamily E polypeptide 1 (CYP2E1 ) [4], Cytochrome P450 family 1 subfamily A polypeptide 2 (CYP1A2 ) [5] and Serpin peptidase inhibitor clade A member 1 (Alpha 1-antitrypsin ) [6]. HNF1-alpha is a major regulator ofglucose homeostasis [1]. It regulates transcription of Solute carrier family5 (sodium/glucose cotransporter) member 1 ( SLC5A1 ) [7], Solutecarrier family 2 (facilitated glucose transporter) member 2 ( GLUT2 ) [8]. In addition, HNF1-alpha activates transcription of insulin/energysignaling proteins, specifically of Insulin [9], Insulin-likegrowth factor binding protein 1 ( IBP1 ) [10], and Islet amyloidpolypeptide ( Amylin ) [2].

Both HNF1-alpha and HNF1-beta stimulate transcription of developmentalsignaling proteins, such as Retina and anterior neural fold homeobox ( RAX )[11], Pancreatic and duodenal homeobox 1 ( Pdx-1 (IPF1) ) [12], Nuclear receptor subfamily 5 group A member 2 ( LRH1 ) [13]and others.

In addition, HNF1-alpha and HNF1-beta activate transcription of manycholesterol transporters (Apolipoproteins A1, A2 and B ( APOA1 [14],APOA2 [15], and APOB [11]), ATP-binding cassette,sub-family A member 1 ( ABCA1 ) [16]) and ion channel proteins (Cysticfibrosis transmembrane conductance regulator ( CFTR ) [17], Solutecarrier family 4 anion exchanger member 2 ( SLC4A2 ) [18], Polycystickidney disease 2 ( Polycystin 2 ) [19] and others).