Map Key
Generic Enzyme
Generic kinase
Protein kinase
Lipid kinase
Generic phosphatase
Protein phosphatase
Lipid phosphatase
Generic phospholipase
Generic protease
Metalloprotease
G-alpha
RAS - superfamily
G beta/gamma
Regulators (GDI, GAP, GEF)
Generic channel
Ligand-gated channel
Voltage-gated channel
Transporter
Normal process
Pathological process
Positive effect
Negative effect
Unspecified effect
Technical link
Disrupts in disease
Emerges in disease
Enhances in disease
Weakens in disease
Organsim specific interaction

Generic binding protein
Receptor ligand
Cell membrane glycoprotein
Transcription factor
DNA
RNA
Compound
Inorganic ion
Predicted metabolite or user's structure
Reaction
Generic receptor
GPCR
Receptors with enzyme activity
Mitochondria
EPR
Golgi
Nucleus
Lysosome
Peroxisome
Cytoplasm
Extracellular

Normal process
Pathological process
Binding
Cleavage
Covalent modifications
Phosphorylation
Dephosphorylation
Transformation
Transport
Catalysis
Transcription regulation
MicroRNA binding
Competition
Influence on expression
Unspecified interactions
Pharmacological effect
Toxic effect
Group relation
Complex subunit
Similarity reaction
A complex or a group
Organism specific object

Cytoskeleton remodeling Slit-Robo signaling


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Cytoskeleton remodeling Slit-Robo signaling

SLIT-ROBO signaling

Attractive and repulsive receptors regulate cell motility and attachment in axonguidance, vascular growth, immune cell regulation and tumor progression. There is strongevidence that development of the nervous and vascular systems is controlled by commoncues.

Semaphorins, Ephrins, SLITs and Netrins are the four major guidance factors.Their cognate receptors are Plexins and Neuropilins, Ephs, ROBOs, UNC5 andDCC.

SLITs belong to repulsive cues. Intracellular molecular mechanisms leading torepulsive responses involve cytoskeletal reorganization.

Small GTPases play important role in this signaling [1].

Another signaling pathway that guidance signals to the regulation of cytoskeletaldynamics is the c-Abl protein kinase pathway. This pathway mediates signalsdownstream of the multiple ROBO receptors [2].