Lab Water Gets “Ultra-Ultrapure”
New polisher removes trace organics detected by the most sensitive chromatography instrumentsAlthough industry standard Milli-Q® water has long been a satisfactory solution for these advanced techniques, recent advances have increased the sensitivity of organic and biochemical molecule detection. As a result, chromatographers increasingly need higher quality ultrapure water for use in mobile phase, buffers, blanks and standards, as well as for sample dilution, glassware rinsing, and extraction. The unique LC-Pak cartridge provides ultrapure water with an extremely low level of organics at a fraction of the cost of commercially available bottled water for chromatography.
The LC-Pak cartridge contains tightly packed C18 reverse phase silica that binds organic molecules through hydrophobic interactions. It is easily connected to the outlet of a Milli-Q water dispenser (Q-POD®) or any Millipore Type I water purification system (Milli-Q, Direct-Q®, Synergy® or Simplicity® system). The cartridge produces at least 500 L of ultrapure water suitable for trace organics analysis when fed with ultrapure water with a TOC level below 5 ppb.
“To ensure the water quality meets the most demanding requirements, we put the LC-Pak cartridge through an extensive validation process,” said Millipore Lab Water Group Product Manager, Jean-François Pilette. “Freshly produced ultrapure water from a Milli-Q system fitted with an LC-Pak cartridge was compared with several types of commercial bottled water for LC-MS,” he continued. “Results showed that water produced with the Milli-Q /LC-Pak combination matched or exceeded the quality of commercially-available water.” Details of this study are provided in the LC-Pak Validation Guide.
The LC-Pak cartridge is the latest addition to Millipore’s suite of application-specific point-of-use (POU) polishers. Other POU filters include:
- VOC-Pak™ cartridges for removal of volatile organics from ultrapure water.
- EDS-Pak® point-of-use polishers for production of endocrine disrupter-free water.
- BioPak® ultrafiltration cartridges for preparation of pyrogen- and nuclease-free ultrapure water for use in cell culture, biochemistry, or molecular biology applications.
- Millipak® filters for removal of particulates and bacteria in ultrapure water for analytical applications (spectrophotometry, spectroscopy and chromatography).
All of these POU filters can be used as a final purification step with the Milli-Q Integral, Milli-Q Advantage, Direct-Q, Synergy and Simplicity systems.
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Additional Resources
LC-Pak technical literature: www.millipore.com/lcpak
Integral water system: www.millipore.com/integral
About Millipore
Millipore (NYSE: MIL) is a life science leader providing cutting-edge technologies, tools, and services for bioscience research and biopharmaceutical manufacturing. As a strategic partner, we collaborate with customers to confront the world’s challenging human health issues. From research to development to production, our scientific expertise and innovative solutions help customers tackle their most complex problems and achieve their goals. Millipore Corporation is an S&P 500 company with more than 5,900 employees worldwide. For more information, please contact Millipore tech service at 1-800-548-7853 or 951-676-8080 or visit www.millipore.com
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Greg Hoff
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978-762-5170
greg_hoff@millipore.com
Millipore, Milli-Q, Direct-Q, Synergy, Simplicity, EDS-Pak, BioPak and Millipak are registered trademarks of Millipore Corporation. LC-Pak, VOC-Pak, the M Mark, and ADVANCING LIFE SCIENCE TOGETHER are trademarks of Millipore Corporation. UPLC is a registered trademark of Waters Investment Limited Corporation.
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