Millipore Offers ArthroMAB™ Monoclonal Antibody Cocktail for Arthritis Research

Billerica, Massachusetts—August 27, 2007—Millipore today announced the availability of ArthroMAB™ Monoclonal Antibody Cocktail, a kit researchers use to generate arthritis mouse models. These models are used for rapid screening and evaluation of anti-inflammatory therapeutics. ArthroMAB™ initiates arthritis via immune complex formation on the surface of cartilage in joints.

ArthroMAB™ is a cocktail of four monoclonal antibodies directed against Collagen. It rapidly induces robust arthritis in all four paws of a variety of mouse strains (e.g., Balb/C–CIA resistant, DBA/1, B10.RIII). Compared to the traditional collagen induced arthritis (CIA) model, the ArthroMAB™ kit (which includes antibody cocktail and bacterial lipopolysaccharide (LPS)), induces severe arthritis in mice within days instead of weeks and allows researchers to test far fewer animals since the incidence of arthritis is nearly 100%. Furthermore, synchronized disease onset between mice reduces treatment schedules and simplifies assessment studies, when compared to other arthritis models.

Millipore’s Bioscience Division provides innovative tools, services and biological reagents that drive advancements in biomedical and academic research as well as support the discovery and development of new pharmaceuticals. The product portfolio has been further enhanced with the 2006 addition of Chemicon^®, Upstate^® and Linco^® product lines, allowing Millipore to provide the most complete offering of life science tools on the market. Our customers work in leading research laboratories across a variety of industries throughout the world. Millipore improves their laboratory productivity and efficiency through optimized workflows. For more information, please contact Millipore Tech Service at 1-800-548-7853 or 951-676-8080 or visit www.millipore.com.


About Millipore

Millipore is a leading provider of products and services that improve productivity in laboratory research and bioprocessing manufacturing sites. Through its broad product portfolio, the Company drives growth through innovation and delivers higher value-added applications to the marketplace. Millipore experts have a comprehensive understanding of customers’ research, which results in superior tools, technologies and services. The Company is part of the S&P 500 index and employs approximately 6,000 employees in more than 47 countries worldwide. For additional information on Millipore Corporation, please visit www.millipore.com.

Millipore, Chemicon, Linco, and Upstate are registered trademarks of Millipore Corporation. ArthroMAB is a trademark of Millipore Corporation.

MILLIPORE NEWS
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Lauren Nolan
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Millipore Corporation
978-762-5080
lauren_nolan@millipore.com