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Millipore and Cellumen Announce CellCiphr™ Cytotoxicity Profiling Assay Kit


Billerica, Massachusetts—August 7, 2007—Millipore Corporation today announced the availability of the CellCiphr Cytotoxicity Profiling Assay Kit using human HepG2 cells. This assay panel effectively detects drug-induced hepatotoxicity and is expected to be used early in the drug discovery process.

The CellCiphr Cytotoxicity Profiling Panel uses human HepG2 cells in an assay comprised of high-quality, validated, multiplexed detection reagents and protocols for testing pre-clinical compounds against well recognized cytotoxicity parameters. The assay was developed in collaboration with Cellumen and their proprietary Cellular Systems Biology approach to investigating cytotoxicity. Hence, profiling compounds with this assay panel takes advantage of the imaging, sensitivity and multiplexing capability of high content screening instruments (HCS).

The ability to recognize potential hepatotoxicity sooner in the drug development pipeline may reduce the cost of identifying toxicity in expensive animal studies. The CellCiphr Panel provides multiplexed HCS analysis of 11 human cytotoxicity parameters over three time points (acute at 30 minutes, early at 24 hours and chronic at 72 hours), generating 10-point dose response curves in duplicate for up to 16 test compounds and four control toxins.

Millipore’s Bioscience Division provides innovative tools, services and biological reagents that drive advancements in biomedical and academic research as well as support the discovery and development of new pharmaceuticals. The product portfolio has been further enhanced with the 2006 addition of Chemicon®, Upstate® and Linco® product lines, allowing Millipore to provide the most complete offering of life science tools on the market. Our customers work in leading research laboratories across a variety of industries throughout the world. Millipore improves their laboratory productivity and efficiency through optimized workflows. For more information, please contact Millipore Tech Service at 1-800-548-7853 or 951-676-8080 or visit www.millipore.com.

About Millipore

Millipore is a leading provider of products and services that improve productivity in laboratory research and bioprocessing manufacturing sites. Through its broad product portfolio, the Company drives growth through innovation and delivers higher value-added applications to the marketplace. Millipore experts have a comprehensive understanding of customers’ research, which results in superior tools, technologies and services. The Company is part of the S&P 500 index and employs approximately 5,800 employees in more than 47 countries worldwide. For additional information on Millipore Corporation, please visit www.millipore.com.

About Cellumen

Cellumen, Inc. is the Cellular Systems Biology Company. Cellumen focuses on the cell as an integrated and interacting network of genes, proteins and metabolites responsible for normal and abnormal (disease) function. To promote efficient drug discovery and development, the company offers solutions to the dual challenges of efficacy and toxicity. The company’s products and services have application in each of the major segments of the pharmaceutical pipeline: drug discovery (“cellular models of disease”), drug development (“cytotoxicity profiling”) and clinical trials (“patient sample profiling”). The Cellumen team leverages its experience and expertise in High Content Screening, cell-based assays, advanced reagents and bioinformatics to create high value solutions. Cellumen’s profiling services for cellular models of disease and cytotoxicity profiling are available today. For more information, please visit www.cellumen.com.

Millipore, Chemicon, Upstate, and Linco are registered trademarks of Millipore Corporation. CellCiphr is a trademark of Cellumen Inc.

MILLIPORE NEWS
For immediate release
Media Contact:

Lauren Nolan
Communications Specialist
Millipore Corporation
978-762-5080
lauren_nolan@millipore.com



Media Contact

For media inquiries, company news and community outreach:

Karen Marinella Hall
Director, Corporate Communications
Tel: 978-715-1567
Karen_Hall@millipore.com

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