Millipore Applications Bibliography |
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Potential regulatory function of human dendritic cells expressing indoleamine 2,3-dioxygenase. | ||
| Authors: | Munn, David H, et al. | |
| Citation: | Science, 297: 1867-70 (2002) | |
| Pub Med ID: | 12228717 | |
| Year: | 2002 | |
| Abstract: | Antigen-presenting cells (APCs) can induce tolerance or immunity. We describe a subset of human APCs that express indoleamine 2,3-dioxygenase (IDO) and inhibit T cell proliferation in vitro. IDO-positive APCs constituted a discrete subset identified by coexpression of the cell-surface markers CD123 and CCR6. In the dendritic cell (DC) lineage, IDO-mediated suppressor activity was present in fully mature as well as immature CD123+ DCs. IDO+ DCs could also be readily detected in vivo, which suggests that these cells may represent a regulatory subset of APCs in humans. | |
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