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Potential regulatory function of human dendritic cells expressing indoleamine 2,3-dioxygenase.
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| Author |
Munn, David H, et al. |
| Citation Information |
Science, 297: 1867-70 (2002), : (2002) |
| Related Products |
05-840, AB5968 |
| Pub Med ID |
12228717 |
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Abstract
Antigen-presenting cells (APCs) can induce tolerance or immunity. We describe a subset of human APCs that express indoleamine 2,3-dioxygenase (IDO) and inhibit T cell proliferation in vitro. IDO-positive APCs constituted a discrete subset identified by coexpression of the cell-surface markers CD123 and CCR6. In the dendritic cell (DC) lineage, IDO-mediated suppressor activity was present in fully mature as well as immature CD123+ DCs. IDO+ DCs could also be readily detected in vivo, which suggests that these cells may represent a regulatory subset of APCs in humans.
