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The RAF proteins take centre stage.

Author	Wellbrock, Claudia, et al.
Citation Information	Nat. Rev. Mol. Cell Biol., 5: 875-85 (2004), : (2004)
Related Products	05-739, 05-538MG, 21-111, 14-557, 17-359, 07-583, 05-534, 05-538, 14-530, 62-086, 07-396, 14-352, 17-357, 60-109, 62-085, 17-358, 07-453
Pub Med ID	15520807

Since their discovery over 20 years ago, the RAF proteins have been intensely studied. For most of that time, the focus of the field has been the C-RAF isoform and its role as an effector of the RAS proteins. However, a report that implicates B-RAF in human cancer has highlighted the importance of all members of this protein kinase family and recent studies have uncovered intriguing new data relating to their complex regulation and biological functions.