Content Loading...
Content Loading...
Last Item Added: 0 Items
Content Loading...
» Close

Product Reference

Focal adhesion kinase: in command and control of cell motility.

   
Author Mitra, Satyajit K, et al.
Citation Information Nat. Rev. Mol. Cell Biol., 6: 56-68 (2005), : (2005)
Related Products 16-233
Pub Med ID 15688067
   

Abstract

A central question in cell biology is how membrane-spanning receptors transmit extracellular signals inside cells to modulate cell adhesion and motility. Focal adhesion kinase (FAK) is a crucial signalling component that is activated by numerous stimuli and functions as a biosensor or integrator to control cell motility. Through multifaceted and diverse molecular connections, FAK can influence the cytoskeleton, structures of cell adhesion sites and membrane protrusions to regulate cell movement.