Millipore Applications Bibliography |
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Focal adhesion kinase: in command and control of cell motility. | ||
| Authors: | Mitra, Satyajit K, et al. | |
| Citation: | Nat. Rev. Mol. Cell Biol., 6: 56-68 (2005) | |
| Pub Med ID: | 15688067 | |
| Year: | 2005 | |
| Abstract: | A central question in cell biology is how membrane-spanning receptors transmit extracellular signals inside cells to modulate cell adhesion and motility. Focal adhesion kinase (FAK) is a crucial signalling component that is activated by numerous stimuli and functions as a biosensor or integrator to control cell motility. Through multifaceted and diverse molecular connections, FAK can influence the cytoskeleton, structures of cell adhesion sites and membrane protrusions to regulate cell movement. | |
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