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Product Reference
Focal adhesion kinase: in command and control of cell motility.
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| Author |
Mitra, Satyajit K, et al. |
| Citation Information |
Nat. Rev. Mol. Cell Biol., 6: 56-68 (2005), : (2005) |
| Related Products |
16-233 |
| Pub Med ID |
15688067 |
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Abstract
A central question in cell biology is how membrane-spanning receptors transmit extracellular signals inside cells to modulate cell adhesion and motility. Focal adhesion kinase (FAK) is a crucial signalling component that is activated by numerous stimuli and functions as a biosensor or integrator to control cell motility. Through multifaceted and diverse molecular connections, FAK can influence the cytoskeleton, structures of cell adhesion sites and membrane protrusions to regulate cell movement.
