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Product Reference
BRCA1 is a cell cycle-regulated nuclear phosphoprotein.
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| Author |
Ruffner, H and Verma, I M |
| Citation Information |
Proc. Natl. Acad. Sci. U.S.A., 94: 7138-43 (1997), : (1997) |
| Related Products |
07-007, 07-635 |
| Pub Med ID |
9207057 |
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Abstract
We have characterized the BRCA1 gene product by using four polyclonal antibodies raised against peptides from four different regions of the protein. The antibodies specifically recognize an approximately 220-kDa BRCA1 protein that is predominantly expressed in the nucleus of both normal and neoplastic breast cancer cells. It is a serine phosphoprotein that undergoes hyperphosphorylation during late G1 and S phases of the cell cycle and is transiently dephosphorylated early after M phase. We propose that BRCA1 is a phosphoprotein that alters in a qualitative and quantitative manner during cell cycle progression.
