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Transmitter sensitivity of neurons assayed by autoradiography.

   
Author Yoshikami, D
Citation Information Science, 212: 929-30 (1981), : (1981)
Related Products AB1568-2000T
Pub Med ID 6262911
   

Abstract

Ionic conductance channels that are opened by activating nicotinic acetylcholine receptors at synapses of sympathetic neurons are permeable to small organic amines. Uptake of a tritium-labeled amine through these channels can be measured by autoradiography. This provides a simple and direct way to assess the sensitivity of individual neurons to acetylcholine without using microelectrodes.