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Product Reference
Catenins as mediators of the cytoplasmic functions of cadherins.
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| Author |
Gumbiner, B M and McCrea, P D |
| Citation Information |
J. Cell Sci. Suppl., 17: 155-8 (1993), : (1993) |
| Related Products |
AB19021 |
| Pub Med ID |
8144692 |
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Abstract
The catenins are polypeptides that bind to the conserved cytoplasmic tail of cadherins and are required for cadherin function. alpha-Catenin is related to vinculin and seems to be required for the interaction of cadherins with the actin cytoskeleton. beta-Catenin is homologous to armadillo, a segment polarity gene in Drosophila that participates in developmental signaling. Recent findings indicate that beta-catenin also participates in developmental signaling and embryonic patterning in Xenopus laevis. At least a portion of the electrophoretic band migrating at the position of gamma-catenin consists of plakoglobin, a desmosomal and zonula adherens protein that has high sequence similarity to beta-catenin and armadillo. The catenins may be involved in the regulation of cadherin function during tissue morphogenesis and tumorigenesis.
