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Turning blood into brain: cells bearing neuronal antigens generated in vivo from bone marrow.
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| Author |
Mezey, E, et al. |
| Citation Information |
Science, 290: 1779-82 (2000), : (2000) |
| Related Products |
MAB377 |
| Pub Med ID |
11099419 |
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Abstract
Bone marrow stem cells give rise to a variety of hematopoietic lineages and repopulate the blood throughout adult life. We show that, in a strain of mice incapable of developing cells of the myeloid and lymphoid lineages, transplanted adult bone marrow cells migrated into the brain and differentiated into cells that expressed neuron-specific antigens. These findings raise the possibility that bone marrow-derived cells may provide an alternative source of neurons in patients with neurodegenerative diseases or central nervous system injury.
