Content Loading...
Content Loading...
Product Reference
A Drosophila model of Parkinson's disease.
| |
|
| Author |
Feany, M B and Bender, W W |
| Citation Information |
Nature, 404: 394-8 (2000), : (2000) |
| Related Products |
AB152, AB1690 |
| Pub Med ID |
10746727 |
| |
|
Abstract
Parkinson's disease is a common neurodegenerative syndrome characterized by loss of dopaminergic neurons in the substantia nigra, formation of filamentous intraneuronal inclusions (Lewy bodies) and an extrapyramidal movement disorder. Mutations in the alpha-synuclein gene are linked to familial Parkinson's disease and alpha-synuclein accumulates in Lewy bodies and Lewy neurites. Here we express normal and mutant forms of alpha-synuclein in Drosophila and produce adult-onset loss of dopaminergic neurons, filamentous intraneuronal inclusions containing alpha-synuclein and locomotor dysfunction. Our Drosophila model thus recapitulates the essential features of the human disorder, and makes possible a powerful genetic approach to Parkinson's disease.
