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Tyrosine hydroxylase-based DNA-vaccination is effective against murine neuroblastoma. | ||
| Authors: | Lode, H N, et al. | |
| Citation: | Med. Pediatr. Oncol., 35: 641-6 (2000) | |
| Pub Med ID: | 11107137 | |
| Year: | 2000 | |
| Abstract: | BACKGROUND: The disruption of self-tolerance against neuroblastoma is the ultimate goal of an effective DNA-vaccine. PROCEDURE: Here we demonstrate the induction of a protective immunity against syngeneic murine NXS2 neuroblastoma in A/J mice, following vaccination with tyrosine hydroxylase (TH) derived antigens. Oral gene delivery was accomplished using an attenuated strain of Salmonella typhimurium as a carrier harboring vectors encoding for mTH antigens. RESULTS: Vaccination was effective in protecting animals from a lethal challenge with wild-type NXS2 tumor cells. CONCLUSIONS: These results provide the first evidence of the TH self antigen being recognized by T-cells and demonstrate that a TH-based DNA vaccine is a potentially useful immunotherapeutic strategy for neuroblastoma. | |
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