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Region-specific generation of cholinergic neurons from fetal human neural stem cells grafted in adult rat.
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| Author |
Wu, Ping, et al. |
| Citation Information |
Nat. Neurosci., 5: 1271-8 (2002), : (2002) |
| Related Products |
LIF1010, LIF1005, AB144, AB144P, AP144P-200UL, AB144P-1ML, AB152, AB1543, AB1543P, AB5804, MAB342, MAB377, MAB1281 |
| Pub Med ID |
12426573 |
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Abstract
Pluripotent or multipotent stem cells isolated from human embryos or adult central nervous system (CNS) may provide new neurons to ameliorate neural disorders. A major obstacle, however, is that the majority of such cells do not differentiate into neurons when grafted into non-neurogenic areas of the adult CNS. Here we report a new in vitro priming procedure that generates a nearly pure population of neurons from fetal human neural stem cells (hNSCs) transplanted into adult rat CNS. Furthermore, the grafted cells differentiated by acquiring a cholinergic phenotype in a region-specific manner. This technology may advance stem cell-based therapy to replace lost neurons in neural injury or neurodegenerative disorders.
