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Region-specific generation of cholinergic neurons from fetal human neural stem cells grafted in adult rat. | ||
| Authors: | Wu, Ping, et al. | |
| Citation: | Nat. Neurosci., 5: 1271-8 (2002) | |
| Pub Med ID: | 12426573 | |
| Year: | 2002 | |
| Abstract: | Pluripotent or multipotent stem cells isolated from human embryos or adult central nervous system (CNS) may provide new neurons to ameliorate neural disorders. A major obstacle, however, is that the majority of such cells do not differentiate into neurons when grafted into non-neurogenic areas of the adult CNS. Here we report a new in vitro priming procedure that generates a nearly pure population of neurons from fetal human neural stem cells (hNSCs) transplanted into adult rat CNS. Furthermore, the grafted cells differentiated by acquiring a cholinergic phenotype in a region-specific manner. This technology may advance stem cell-based therapy to replace lost neurons in neural injury or neurodegenerative disorders. | |
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