Millipore Applications Bibliography |
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High-speed imaging reveals neurophysiological links to behavior in an animal model of depression. | ||
| Authors: | Airan, Raag D, et al. | |
| Citation: | Science, 317: 819-23 (2007) | |
| Pub Med ID: | 17615305 | |
| Year: | 2007 | |
| Abstract: | The hippocampus is one of several brain areas thought to play a central role in affective behaviors, but the underlying local network dynamics are not understood. We used quantitative voltage-sensitive dye imaging to probe hippocampal dynamics with millisecond resolution in brain slices after bidirectional modulation of affective state in rat models of depression. We found that a simple measure of real-time activity-stimulus-evoked percolation of activity through the dentate gyrus relative to the hippocampal output subfield-accounted for induced changes in animal behavior independent of the underlying mechanism of action of the treatments. Our results define a circuit-level neurophysiological endophenotype for affective behavior and suggest an approach to understanding circuit-level substrates underlying psychiatric disease symptoms. | |
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