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The tumor suppressor Pml regulates cell fate in the developing neocortex.

Author	Tarik Regad, Cristian Bellodi, Pierluigi Nicotera, Paolo Salomoni, Tarik Regad, Cristian Bellodi, Pierluigi Nicotera, Paolo Salomoni, Tarik Regad, Cristian Bellodi, Pierluigi Nicotera, Paolo Salomoni
Citation Information	Nature neuroscience, 12:132-40 (2009)
Keywords	Animals, Cell Differentiation, Cell Division, Cells, Cultured, Female, Gene Expression Regulation, Developmental, Male, Mice, Mice, Mutant Strains, Neocortex, Neuroglia, Neurons, Nuclear Proteins, Organ Size, Phosphorylation, Pregnancy, Protein Phosphatase 1, Retinoblastoma Protein, Stem Cells, Transcription Factors, Tumor Suppressor Proteins
Related Products	05-718, AB980
Pub Med ID	19136970

The control of cell fate in neural progenitor cells is critical for nervous system development. Nevertheless, the processes involved are only partially known. We found that the expression of the tumor suppressor Pml was restricted to neural progenitor cells (NPCs) in the developing neocortex of the mouse. Notably, in Pml(-/-) cortices, the overall number of proliferating NPCs was increased and transition between the two major progenitor types, radial glial cells and basal progenitors, was impaired. This in turn resulted in reduced differentiation and an overall decrease in the thickness of the cortex wall. In NPCs, Pml regulated the subcellular distribution of the retinoblastoma protein (pRb) and the protein phosphatase 1alpha, triggering pRb dephosphorylation. Together, these findings reveal an unexpected role of Pml in controlling the function of NPCs in the CNS.