Millipore Home

• Home
• Products
• Services
• Learning Center
• Tech Library
• Support
• Company

Product Reference

FLASH is an essential component of Cajal bodies.

Author	D Barcaroli, D Dinsdale, M H Neale, L Bongiorno-Borbone, M Ranalli, E Munarriz, A E Sayan, J M McWilliam, T M Smith, E Fava, R A Knight, G Melino, V De Laurenzi
Citation Information	Proceedings of the National Academy of Sciences of the United States of America, 103:14802-7 (2006)
Keywords	Animals, Apoptosis Regulatory Proteins, Calcium-Binding Proteins, Coiled Bodies, Down-Regulation, Hela Cells, Humans, Mice, Nuclear Localization Signals, Nuclear Proteins, Protein Biosynthesis, Protein Transport, Recombinant Fusion Proteins
Related Products	S7100
Pub Med ID	17003126

Cajal bodies are small nuclear organelles with a number of nuclear functions. Here we show that FLICE-associated huge protein (FLASH), originally described as a component of the apoptosis signaling pathway, is mainly localized in Cajal bodies and is essential for their structure. Reduction in FLASH expression by short hairpin RNA results in disruption of the normal architecture of the Cajal body and relocalization of its components. Because the function of FLASH in the apoptosis receptor signaling pathway has been strongly questioned, we have now identified a clear function for this protein.