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Mitochondrial pathway mediates the antileukemic effects of Hemidesmus indicus, a promising botanical drug.
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| Author |
Fimognari, Carmela, et al. |
| Citation Information |
PLoS ONE, 6: e21544 (2011), : (2011) |
| Related Products |
0500-1430, 4000-0040 |
| Pub Med ID |
21738701 |
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Abstract
Although cancers are characterized by the deregulation of multiple signalling pathways, most current anticancer therapies involve the modulation of a single target. Because of the enormous biological diversity of cancer, strategic combination of agents targeted against the most critical of those alterations is needed. Due to their complex nature, plant products interact with numerous targets and influence several biochemical and molecular cascades. The interest in further development of botanical drugs has been increasing steadily and the FDA recently approved the first new botanical prescription drug. The present study is designed to explore the potential antileukemic properties of Hemidesmus indicus with a view to contributing to further development of botanical drugs. Hemidesmus was submitted to an extensive in vitro preclinical evaluation.
