Product Reference
Motesanib inhibits Kit mutations associated with gastrointestinal stromal tumors.
| |
|
| Author |
Sean Caenepeel,Lisa Renshaw-Gegg,Angelo Baher,Tammy L Bush,Will Baron,Todd Juan,Raffi Manoukian,Andrew S Tasker,Anthony Polverino,Paul E Hughes |
| Citation Information |
Journal of experimental & clinical cancer research : CR, 29: (2010) |
| Keywords |
Animals,Blotting, Western,Cell Proliferation,CHO Cells,Cricetinae,Cricetulus,Female,Gastrointestinal Stromal Tumors,Humans,Indoles,Mice,Mice, Inbred C57BL,Mutation,Niacinamide,Phosphorylation,Proto-Oncogene Proteins c-kit |
| Related Products |
05-777 |
| Pub Med ID |
20633291 |
| |
|
Activating mutations in Kit receptor tyrosine kinase or the related platelet-derived growth factor receptor (PDGFR) play an important role in the pathogenesis of gastrointestinal stromal tumors (GIST).
